| CODE | 107034 |
|---|---|
| ACADEMIC YEAR | 2021/2022 |
| CREDITS |
|
| SCIENTIFIC DISCIPLINARY SECTOR | BIO/12 |
| TEACHING LOCATION |
|
| SEMESTER | 2° Semester |
| TEACHING MATERIALS | AULAWEB |
Clinical biochemistry studies the clinical significance of laboratory tests. During the course we will systematically address the study of laboratory medicine of the main organs and functions, which is a key part of the diagnostic reasoning process.
The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of specific organs/functions. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests.
Biochemistry and physiology
Face-to-face or video-recorded lessons (in presence), available on aulaweb
Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.
1-BLOOD
The complete blood count
Electrophoretic profile of serum proteins and its diagnostic interpretation
Principal serum enzymes of diagnostic interest
Non-protein nitrogen
Iron metabolism, quantitative and qualitative defects of hemoglobin
Electrolytes
Morphological and pathognetic classification of anemias
2-LIVER FUNCTION TESTS
Enzymes, bilirubin and jaundice, modifications of serum proteins in selected liver diseases, coagulation factors, diagnosis of selected liver diseases
3-GLUCOSE METABOLISM
Hormones regulating glycemia
Causes of hyper- and hypo-glycemia
Lab tests in diabetes mellitus
Lab tests in chetoacidosis, glucose tolerance test, gestational diabetes.
4-LIPID METABOLISM
Lipoprotein classification and function
Reference values for blood lipids
Hyperlipidemic profiles and cardiovascular risk
5-URINE ANALYSIS AND TESTS OF RENAL FUNCTION
The physical-chemical urineanalysis
Renal functional tests: indicators of glomerular and tubular malfunction
6-TESTS FOR ENDOCRINE DISORDERS
Steroid, peptide and aminoacid-derived hormones: basal levels and pathologic conditions of hyper/hypo-secretion
Lab tests in the diagnosis of endocrinological disorders
7- HEART
Markers of myocardial necrosis and ischemia
Markers of heart failure
8-TESTS OF PANCREATIC FUNCTION
9-ARTERIAL BLOOD GASES AND ACID-BASE BALANCE
10-INFLAMMATION
Common markers of inflammation
Specific markers of inflammation for selected (auto)inflammatory and autoimmune diseases
on-line available (aula web) slides
Common laboratory tests - Vaughn G. Appleton & Lange
Office hours: On-demand tutorials and questions, either in presence (at DIMES, Sez. Biochimica, Viale Benedetto XV 1, 1st floor) or via the Teams platform, by appointment (ezocchi@unige.it).
ELENA ZOCCHI (President)
SANTINA BRUZZONE
The examination will consist of a written test (multiple-choice quiz) or an oral interview, in line with the University's regulations regarding anti-covid safety standards.
Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.
The exam will verify the achievement of the formative objectives; in particular, it will ascertain the student's knowledge of the clinical meaning of the biochemical-clinical parameters presented during the lessons, of the unit of measure in which they are expressed and of their dynamic range in the main pathologies for which they represent a diagnostic-prognostic tool. The ability to choose, among some proposed tests, those suitable to solve a specific diagnostic question, and the ability to identify deviations from the norm indicative of pathology, will be evaluated.