CODE 34001 ACADEMIC YEAR 2022/2023 CREDITS 4 cfu anno 3 CHIMICA E TECNOLOGIE CHIMICHE 8757 (L-27) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/06 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Chemistry and Chemical Technologies 8757 (coorte 2020/2021) LABORATORY OF ORGANIC CHEMISTRY 65111 2020 ORGANIC CHEMISTRY 2 65113 2020 MATHEMATICAL INSTITUTIONS 72564 2020 TEACHING MATERIALS AULAWEB AIMS AND CONTENT LEARNING OUTCOMES To give a general idea of various aspects where organic chemistry is connected with biology. In particular: structure functioning of proteins (enzymes, receptors, channels) and oligosaccharides, and their interaction with potential drugs. AIMS AND LEARNING OUTCOMES Aims The students will be guided to approximately understand the issues associated with drug discovery and with the study of èprpteins and nucleic acids. TEACHING METHODS Traditional lessons in the classroom (32 hours). The attendance is not compulsory but, for statistical means, it wil be anyway monitored. SYLLABUS/CONTENT Protein: secondary, tertiary and quaternary structure Enzymes: kynetics, catalysis mechanism, examples, classification . Nucleic acids: structure, RNA function. Determination of primary structure. PCR. Topoisomers. Genetic mutations. Principle of drug discovery: Enzyme inhibitors, receptors, ion channels. Glycochemistry. Applications in the fields of antiviral, antitumor drugs, antibiotics, antiinflammatory drugs, anti-asthma drugs, drugs for cardiovascular diseases and so on. RECOMMENDED READING/BIBLIOGRAPHY Silverman, R.B., "The Organic Chemistry of Drug Design and Drug Action", Academic Press Corey, E.J., Czakó, B. Kürti, L., "Molecules and Medicines", Wiley TEACHERS AND EXAM BOARD LUCA BANFI Ricevimento: The teacher is always present in the Department between 8.00 and 13.00 and 15.00 and 18.30 (except in august). The students can come to speak with him in any moment, unless he is engaged in other isntitutional activities. However, it is highly advised to arrange an appointment by E-mail, in order to be sure to find him free. LISA MONI Ricevimento: The teacher is available to receive students by contacting her by email at the following address: lisa.moni@unige.it Exam Board LISA MONI (President) ANDREA BASSO LUCA BANFI (President Substitute) CHIARA LAMBRUSCHINI (Substitute) LESSONS LESSONS START March 6, 2023 (timetable on http://www.chimica.unige.it/didattica/orari_CTC or https://corsi.unige.it/8757) Class schedule BIOORGANIC CHEMISTRY EXAMS EXAM DESCRIPTION The exam will be oral. Only the subjects treated during the lessons (as reported in the slides deposited in aulaweb) will be object of the exam. Students must register to the exam at least 48 hours in advance on https://servizionline.unige.it/studenti/esami/prenotazione ASSESSMENT METHODS The oral exam is always carried out by the two teachers and will last at least 30 minutes. In this way, the commission is definitely able to verify with high accuracy if the student has reached or not the learning outcomes. During the oral exam the student must demonstrate to have reached the learning outcomes, both orally and (most importantly) writing formulas, chemical equations, mechanisms. When the commission will judge that the learning oucomes have not been reached, the students will be invited to repeat the exam in one of the subsequent dates. Exam schedule Data appello Orario Luogo Degree type Note 24/05/2023 15:00 GENOVA Orale 28/06/2023 15:00 GENOVA Orale 19/07/2023 15:00 GENOVA Orale 13/09/2023 15:00 GENOVA Orale 04/10/2023 15:00 GENOVA Orale
