|SCIENTIFIC DISCIPLINARY SECTOR||CHIM/08|
You can take the exam for this unit if you passed the following exam(s):
Prerequisites (for future units)
This unit is a prerequisite for:
The "Analysis of drugs II" course is aimed at third year students of the Single Cycle Master's Degree Course in Pharmaceutical Chemistry and Technology (CTF). The course allows the acquirement of 8 credits and consists of theoretical lessons and practical exercises in the laboratory.
The course deals with the separation of mixtures and the purification of organic substances of pharmaceutical interest, using different methods including chromatography, distillation or crystallization. The isolated substances are subsequently identified through classical qualitative analysis, based on the research of the elements and on the identification of functional groups present in the molecules, followed by the determination of some physical constants, such as melting or boiling point, density, optical rotation. The theoretical lessons are accompanied by practical exercises.
The student will have to acquire the ability to plan and implement qualitative analysis and characterization procedures for identifying drugs or compounds of pharmaceutical interest, featured by an inorganic and organic nature.
The teacher will hold the lectures in the classroom with the help of slides that will be made available to students at the end of each topic. Exercises will be introduced by a short illustrative lesson that will be held in the classroom or in the laboratory. The exercises will be individual.
The course of 8 CFU (96 hrs of commitment in frontal teaching activity per student) is divided into two parts: a theoretical one, consisting of 32 hours of lessons, and a practical one, which includes 64 hours of individual exercises in the laboratory. The practical exercises performed in the laboratory are carried out in close correlation with the topics of the course, as indicated in the following program.
Syllabus: Chemistry Laboratory Safety Rules. Laboratory risk prevention. Inorganic qualitative analysis for the characterization of inorganic drugs and associated impurities. Assay in bunsen flame and in crucible. Systematic search for the anions of groups I-IV. Systematic search for cations of groups I-VI. Organic qualitative analysis based on the research of the elements and on the identification of functional groups present in compounds of pharmaceutical interest. Preliminary tests: organoleptic test, combustion test, organic elemental analysis, solubility, identification tests. Functional group analysis. Determination of some physical constants, such as melting or boiling point, density, refractive index, optical rotation.
F. Savelli, O. Bruno, Analisi chimico farmaceutica – Ed. Piccin
V. Cavrini, V. Andrisano, Principi di analisi farmaceutica – Ed. Esculapio
Office hours: From Monday to Friday, by appointment (via e-mail or telephone).
MICHELE TONELLI (President)
CHIARA BRULLO (Substitute)
ANNA CARBONE (Substitute)
ELENA CICHERO (Substitute)
VALERIA FRANCESCONI (Substitute)
FRANCESCA MUSUMECI (Substitute)
Second semester of the academic year 2022/2023
All class schedules are posted on the EasyAcademy portal.
The exam will be oral and will focus on the topics developed in the theoretical lessons and in the practical laboratory exercises.
Written report of each laboratory exercise. Oral examination.