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PHARMACOLOGY AND PHARMACOTHERAPY (PCT)

CODE 67563
ACADEMIC YEAR 2022/2023
CREDITS
  • 10 cfu during the 4th year of 8451 CHIMICA E TECNOLOGIA FARMACEUTICHE (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/14
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 1° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmaceutical chemistry and technology 8451 (coorte 2019/2020)
    • GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401
    • MATHEMATICS (PCT)(MD) 55402
    • PHYSICS (PCT)(MD) 55404
    • GENERAL PHYSIOLOGY (PHAR)(MD) 60808
    • ORGANIC CHEMISTRY I (PCT)(MD) 60822
    • ORGANIC CHEMISTRY II (PCT)(MD) 60828
    • GENERAL PATHOLOGY (MD PCT) 64192
    • GENERAL PHARMACOLOGY AND TOXICOLOGY (PCT MD) 64200
    • ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555
    • BIOCHEMISTRY AND APPLIED BIOCHEMISTRY (I.C.)(PCT MD) 80520
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course  focuses on the main classes of therapeutics. It aims at providing the knowledge of the mechanisms of drugs action, of  the pharmacokinetic and pharmacological profile of drugs, their use in therapy, their side and adverse effects and the more important pharmacological interactions. 

    AIMS AND CONTENT

    LEARNING OUTCOMES

    At the end of this course, students are capable to manage and  dispense drugs, to manage pharmacovigilance issues and to form and inform people about the correct use of drugs. In addition, students will be able to discuss and evaluate as well the suitable experimental approach (in vitro models) for screening new drugs, for  highlighting the cellular /molecular mechanisms underlying drug efficiency and toxicity to propose the pharmacological characterization and, if possible, the repurposing of drugs for their use in theraphy.

    PREREQUISITES

     Only for students who already attended the classes of biology, physiology, pathology and general pharmacology

    TEACHING METHODS

    Lessons in classroom, (PC - connection to specific web sites), followed by interactive sessions. Because of theCOVID emergency, lessons and examinations will be also carried out at distance or with a blended approach, that will be adopted based on the gravity of the pandemia and on the UNIGE and department recommendations

    SYLLABUS/CONTENT

    Elements of Pharmacosurveillance

    Periferic nervous system and neuromuscolar junction

 ,  

    Anatomy and general function of the periferic nervous system

        

    Cholinergic agonists and antagonists and cholinesterase inhibitory drugs

         

    Adrenergic agonists and antagonists

        

    Pharmacology of neuromuscolar transmission



    Local anesthetics



    Drugs affecting uterine motility



    Drugs used in the treatment of migraine



    Drugs acting at Central nervous system

 level

    Anatomy and general functions of the central nervous system

        

    General Anesthetics



    Drugs effective in the therapy of the epilepsies



    Drugs for Parkinson desease



    Drugs used in the treatment of psychoses



    Treatment of depressive disorders



    Opioids: agonists and antagonists



    Treatment of the anxiety disorders



    Treatment of central nervous system degenerative disorders



    Cardiovascular and renal system



    Drugs for the treatment of cardiac insufficiency and ischemia



    Antiarrhythmic drugs



    Drugs acting on the Renin and angiotensin

 system        

    Antihypertensive agents and the drug therapy of hypertension



    Diuretics



    Immune system and inflammation



    Histamine, bradykinin and their antagonist



    Lipid-derived autacoids: eicosanoids e PAF



    Nonsteroidal Antiinflammatory drugs



    Glucocorticoids



    Immunosuppressive agents and immunostimulants

 

    Drugs acting on the blood

 

    Hematopoietic agents



    Anticoagulant – Thrombolytic – Antiplatelet – Antifribinolytic drugs

         

    Drugs used in the treatment of anemia



    Drugs capable to modify plasmatic lipid levels



    Drugs acting on the bronchial function



    Bronchodilatators and other agents used in the treatment of asthma



    Antitussive agents and mucolitics

 

    Drugs affecting gastrointestinal function



    Agents used for control of gastric acidità and treatment of peptic ulcers

 

    Agents used for diarrhea – costipation – Antiemetics and prokinetic agents



    Hormones and hormone antagonists



    Hypothalamic and pituitary hormones



     Estrogens, progestins, androgens and their antagonists



    Pancreatic hormones – oral hypoglycemic agents



    Agents affecting calcification and bone turnover



    Thyroid and antithyroid drugs



    RECOMMENDED READING/BIBLIOGRAPHY

    Rang HP, Dale MM, Ritter JM et al., Farmacologia , Elsevier , settima edizione

    Annunziato L e Di Renzo GF, Trattato di farmacologia, Idelson Gnocchi, seconda edizione

    Goodman and Gilman The pharmacological basis of therapeutics, Mc Graw Hill

    Govoni S Farmacologia, Casa Editrice Ambrosian

    TEACHERS AND EXAM BOARD

    Exam Board

    ANNA MARIA PITTALUGA (President)

    ERNESTO FEDELE

    CHIARA CERVETTO (Substitute)

    MASSIMO GRILLI (Substitute)

    MANUELA MARCOLI (Substitute)

    MARCO MILANESE (Substitute)

    GUENDALINA OLIVERO (Substitute)

    LUCA RAITERI (Substitute)

    LESSONS

    LESSONS START

    Lesson start is indicated in the "Manifesto degli Studi"  and notified on the web site of the School

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Students will take an oral exam on the date indicated, that will consist of  the discussion of at least four arguments  from different sections of the program afforded in class.

    ASSESSMENT METHODS

    questions  will concern the syllabus contents and will be devoted to evaluate  the comprehension, the elarning skills, the knowledge acquired and their ability to communicate it. 

    Exam schedule

    Date Time Location Type Notes