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PHARMACOGNOSY (PCT MD)

CODE 80461
ACADEMIC YEAR 2022/2023
CREDITS
  • 5 cfu during the 2nd year of 8451 CHIMICA E TECNOLOGIA FARMACEUTICHE (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/14
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 1° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmaceutical chemistry and technology 8451 (coorte 2021/2022)
    • ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course aims at characterizing the main derivatives of natural origin, taking an overview of their active constituents with particular attention to the therapeutic/toxic effects that take place both at the cellular level and in the different organ systems such as the central nervous system, gastrointestinal, cardiovascular, genitourinary, respiratory system and skin, describing also the molecular mechanisms related at the basis of their therapeutic application.

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The general principles of pharmacognosy are described. The main vegetable drugs are described with particular reference to those found in the European and Italian Pharmacopoeia.

    AIMS AND LEARNING OUTCOMES

    The main purposes of the course are: i) to provide the concepts and basics for recognition and knowledge of drugs derived from natural sources, in particular obtained from plants, minerals and animals, ii) to discuss the pharmacological (both pharmacokinetic and pharmacodynamic aspects) and the toxicological profiles of their active constituents, iii) to evaluate their therapeutic use in clinical as well as their potential application in industry and research processes.

    PREREQUISITES

    Basic notions of botany, animal biology, anatomy and physiology. The only prerequisites required are cellular biology and anatomy

    TEACHING METHODS

    The teaching program will be fully developed within a total of 20 classes of 2 hours. Classes could be given by on-line telematic platform when/if necessary

    SYLLABUS/CONTENT

    Introduction to pharmacognosy, definition and classification of natural derivates (from plants, animals, and minerals). The course will outline the factors that affect the variability of the active components content in natural derivates. Natural factors: endogenous or genetic factors, exogenous or environmental factors. artificial factors: the collection and balsamic period, the preparation and preservation by dehydration processes or enzymatic inactivation. Alterations of drugs obtained from natural derivates.
    Overview of the methods of preservation and analysis of drugs obtained from natural derivates, the quality control before marketing and labeling data of the packaging.

    General pharmacology. Diagram of the pharmacokinetics and pharmacodynamics. Therapeutic effect, side effect, and the toxic effect. Mechanisms of interaction between active compounds from natural derivates and synthetic drugs.

    Natural constituents that act on the central and peripheral nervous system. Natural constituents with sympathetic and parasympathetic effects. Natural constituents with neuro-stimulating activities, antidepressant, analgesic, anesthetic, anxiolytic, sedative, hallucinogen, and psychedelic effects, drug of abuse.

    Active natural compounds that affect the cardio-circulatory apparatus. Natural compounds with cardiotonic activity, vasoactive and vasoprotectors, anticoagulant, fibrinolytic, haemostatic antihaemorrhagic.

    Background of immune function and natural immunomodulatory compounds and their mechanism of action, substances with adaptogenic activities.

    Compounds of natural origin which act on the gastrointestinal apparatus. Constituents with eupeptic and mucose-protective activities, choleretic and cholagogues, antispasmodic and carminative, laxatives, anti-diarrheal and  constituents with hypocholesterolemic effetcs.

    Overview of natural compounds with antiparasitic activity, anti-protozoal, anthelmintics, anti-malarials, antibiotics.
    Natural compounds that affect the respiratory system. Expectorants, mucolytics and emollients, balsamic and antiseptic, bronchodilators and anti-asthmatics.

    Active constituents of natural origins that affect the genitourinary apparatus. Antiseptic and diuretic, the main phytoestrogens compounds.

    Compounds of natural origin which act on the muscle-skeletal apparatus and skin. Natural constituents with anti-inflammatory, anti-rheumatic and revulsive activity.

    Compounds of natural origin with antitumor activity.

    Probiotics, prebiotics and nutraceuticals.

    Pharmacovigilance and phytovigilance notions.

    RECOMMENDED READING/BIBLIOGRAPHY

    - Farmacognosia e Fitoterapia: basi farmacolighe e aspetti applicativi (Mazzanti, Dell'Agli, Izzo); PICCIN EDITORE

    - Farmacognosia. Botanica, chimica e farmacologia delle piante medicinali (Capasso); SPRINGER EDITORE.

    - Fondamenti di Farmacognosia e Fitoterapia (Galeotti, Mazzanti, Serafini); EDRA EDITORE

    - Farmacognosia Generale e Applicata (Bruni); PICCIN EDITORE.

    TEACHERS AND EXAM BOARD

    Exam Board

    GUENDALINA OLIVERO (President)

    MARCO MILANESE

    ANGELA BISIO (Substitute)

    TIZIANA BONIFACINO (Substitute)

    CHIARA CERVETTO (Substitute)

    ERNESTO FEDELE (Substitute)

    MASSIMO GRILLI (Substitute)

    MANUELA MARCOLI (Substitute)

    ANNA MARIA PITTALUGA (Substitute)

    LUCA RAITERI (Substitute)

    LESSONS

    LESSONS START

    The beginning of the lessons and the venue will be published on the Department website as soon as they will be available.

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    The examination consists in an oral session. The examination board is always composed by two lecturers (in case of necessity, the examination is conducted by the lecturer and by a graduate student/ postdoc-fellow, recognized by the Department Committee). The exam questions relate to matters dealt during the lectures and allow the board to verify the achievement of the educational objectives of teaching. 

    ASSESSMENT METHODS

    The final mark will take into account the level of competence acquired, the reasoning  and correlation between the different topics of the program and the proper scientific language used during the interview. If the evaluation criteria are not achieved sufficiently, the student will be rejected and invited to deepen the study, using, if necessary, further explanation by the lecturer.

    Exam schedule

    Date Time Location Type Notes
    05/04/2023 09:30 GENOVA Orale
    19/06/2023 09:30 GENOVA Orale
    10/07/2023 09:30 GENOVA Orale
    24/07/2023 09:30 GENOVA Orale
    04/09/2023 09:30 GENOVA Orale
    21/09/2023 09:30 GENOVA Orale
    22/01/2024 09:30 GENOVA Orale
    19/02/2024 09:30 GENOVA Orale