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GENERAL PHARMACOLOGY AND TOXICOLOGY (PCT MD)

CODE 64200
ACADEMIC YEAR 2022/2023
CREDITS
  • 8 cfu during the 3nd year of 8451 CHIMICA E TECNOLOGIA FARMACEUTICHE (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/14
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmaceutical chemistry and technology 8451 (coorte 2020/2021)
    • MATHEMATICS (PCT)(MD) 55402
    • PHYSICS (PCT)(MD) 55404
    • GENERAL AND INORGANIC CHEMISTRY (PHAR)(MD) 55413
    • ORGANIC CHEMISTRY 60795
    • ORGANIC CHEMISTRY II (PCT)(MD) 60828
    • GENERAL PHYSIOLOGY (PCT)MD) 60829
    • ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555
    • BIOCHEMISTRY AND APPLIED BIOCHEMISTRY (I.C.)(PCT MD) 80520
    Prerequisites (for future units)
    This unit is a prerequisite for:
    • Pharmaceutical chemistry and technology 8451 (coorte 2020/2021)
    • PHARMACOLOGY AND PHARMACOTHERAPY (PCT) 67563
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course is transformed by combining with the molecular biology module. The interest for biotechnological drugs will be characterized by in-depth studies and dedicated lessons.

    The course is aimed at providing the bases of pharmacology and toxicology.
    Moreover, will be provided knowledge and tools related to scientific research in this field.

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The course of Pharmacology aims to provide knowledge about the general mechanisms of drug interactions with the biological structures. The course will deal from a qualitative and quantitative point of view:

    • the interactions of drugs with receptors and other proteins
    • the mechanisms of drug absorption, distribution, metabolism, and elimination.
    • the individual variability of the drug response
    • the toxicity of a drug
    • the mechanisms of drug interactions

    AIMS AND LEARNING OUTCOMES

    The goal is to create a solid foundation for dealing with the management of the drug.

    The student will learn what a pharmacological problem means, analyze the efficacy and safety of a drug and evaluate specific cases related to the emerging development of biotechnological drugs

    PREREQUISITES

    General chemistry and inorganic

    Organic chemical I.

    Organic chemical II.

    Biochemistry and applied biochemistry 

    Animal biology and human anatomy 

    Maths

    Physics

    General Physiology

    TEACHING METHODS

    Frontal lectures or, if necessary, in telematic teaching mode.

    SYLLABUS/CONTENT

    1. General Pharmacology and Toxicology
    2. Pharmacodynamics
    3. Pharmacokinetics (PK)
    4. Challenges in Pharmacological Research
    5. Receptors
    6. Ionotropic Rs  (IRs)
    7. Metabotropic R Metabotropy (MRs)
    8. IRs Main families, localization, activities
    9. MRs Main families, localization, activities
    10. Other receptors
    11. Carrier (T)
    12. T Main families, localization, activities
    13. Non-functional Techniques
    14. Functional Techniques
    15. Drug-Receptor interaction (FR)
    16. Pharmacological Theories
    17. FR Constants and parameters
    18. FR Linear and logarithmic graphic representations

    19. Computer software and tools
    20. Allosteric and orthosteric ligands
    21. Absorption
    22. Distribution
    23. Metabolism
    24. Elimination
    25. PK In the elderly
    26. PK In the smoker
    27. PK In the cannabis consumer
    28. PK in the obesity
    29. Routes of administration
    30. Ways of elimination
    31. Metabolism's Phases, genetic variations and processes
    32. PK Parameters and kinetics
    33. Toxicology
    34. Drugs Handling 
    35. Preclinical, and clinical trials
    36. Toxicity test
    37. Mechanisms of Toxicity

    38. ADR and Pharmacovigilance
    39. Forensic toxicology
    40. Contrast liquids

    41 Vaccines and biotechnological drugs

    RECOMMENDED READING/BIBLIOGRAPHY

    Goodman & Gilman Le basi farmacologiche della terapia Zanichelli

    Hitner & Nagle Principi di Farmacologia Zanichelli

    Katzung, Master, Trevor Frmacologia Generale e clinica Piccin

    Casarett & Doull Elementi di tossicologia Casa editrice Ambrosiana

    Tossicologia generale e applicata ai farmaci- Manzo, Paolillo e Vitalone -edra

    Il meccanismo d'azione dei farmaci Francesco Clementi Guido Fumagalli-edra

    Rossi, Cuomo, Riccardi Farmacologia principi di base e applicazioni terapeutiche IV ed Edizioni Minerva Medica

    TEACHERS AND EXAM BOARD

    Exam Board

    MASSIMO GRILLI (President)

    ERNESTO FEDELE

    CHIARA CERVETTO (Substitute)

    MARCO MILANESE (Substitute)

    GUENDALINA OLIVERO (Substitute)

    ANNA MARIA PITTALUGA (Substitute)

    LUCA RAITERI (Substitute)

    LESSONS

    LESSONS START

    Starting date: March 01, 2021

    MS Teams Code: 

    c763qws

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Oral examination (frontal or telematic mode).

    ASSESSMENT METHODS

    The learning outcomes will be based on the assessment during the examination of three key aspects:

    appropriateness of the terminology
    skills and notions
    reasoning ability

    Exam schedule

    Date Time Location Type Notes