CODE 80453 ACADEMIC YEAR 2022/2023 CREDITS 5 cfu anno 5 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/08 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2018/2019) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2018 ORGANIC CHEMISTRY I (PCT)(MD) 60822 2018 ORGANIC CHEMISTRY II (PCT)(MD) 60828 2018 PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II (PCT) 67558 2018 MEDICINAL AND TOXICOLOGICAL CHEMISTRY I 80446 2018 TEACHING MATERIALS AULAWEB OVERVIEW The "DRUGS SYNTHESIS" Teaching program is aimed at students of the fifth year of the Single Cycle Master's Degree Course in Pharmaceutical Chemistry and Technology (CTF). The course allows the acquirement of 5 CFU and consists of a theoretical part and a practice of individual exercises in the synthesis laboratory. AIMS AND CONTENT LEARNING OUTCOMES The course aims to introduce the student to the synthesis techniques applied to the preparation of drugs. AIMS AND LEARNING OUTCOMES In particular, the student must acquire the ability to plan and implement the preparation of certain drugs by applying classic or innovative synthetic pathways (step-by-step, one pot, parallel synthesis, etc.). To apply the main isolation and purification methods of finished products from reaction mixtures, to characterize finished products through common analytical techniques. In addition, the theoretical notions concerning the synthetic methods applied, as well as the necessary and complementary activities of the synthesis (isolation, extraction, purification, anhydration, drying, etc.) will be required. TEACHING METHODS The lecturer will hold the frontal lectures in the classroom with the help of slides that will be made available to students for study at the end of each argument. Exercises will be introduced by a brief lesson that will be held in the classroom or in the same workshop. The exercises will be individual. SYLLABUS/CONTENT The course consists of theoretical lessons and practical exercises. The 5 CFUs (60 hours of frontal learning engagement per student) will be divided into 20 hours of classroom lesson and 40 hours of laboratory exercise. Theoretical lessons: Safety standards in the synthesis lab. The synthesis lab notebook. How to synthesize a drug. Reagents and solvents: choice, storage, use, disposal; The anhydrous solvents. Catalysts. Classic synthesis: the glassware and the main equipment used. Parallel synthesis and combinatorial synthesis: theoretical ideas and equipment. Microwave-assisted reactions: theoretical ideas and equipment. The reactions in the absence of solvent, theoretical considerations. Flow reactions, theoretical outlines and equipment. The purification techniques of reaction mixtures (solvent extraction, chromatographic separation, crystallization, distillation). The characterization of a "finished" compound: the analytical techniques used to determine structure and purity. Exercises Starting from the known drug structure, the student will be guided to plan a synthetic strategy based on the knowledge acquired in the courses of organic chemistry and pharmaceutical chemistry. In addition, the student will be able to conduct online research on specialized databases to verify the existence of known procedures in the literature that can be applied to the lab. The designed synthesis will be carried out in the laboratory and the products obtained will be purified and characterized. RECOMMENDED READING/BIBLIOGRAPHY There are no textbooks covering all the topics in a single volume and therefore the teacher prefers not to give specific indications and instead provide the tools needed by the students to find the necessary information to prepare the exam. The documentation required for experiments will be provided through Aulaweb or in the laboratory. Any bibliographic information relating to the applied synthesis will be obtained through appropriate research on dedicated databases (SCIFINDER, Reaxys) and by the school library system. TEACHERS AND EXAM BOARD MICHELE TONELLI Ricevimento: From Monday to Friday, by appointment (via e-mail or telephone). Exam Board MICHELE TONELLI (President) SILVIA SCHENONE ANNA CARBONE (Substitute) VALERIA FRANCESCONI (Substitute) LESSONS LESSONS START First semester of the academic year 2022/2023 Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Each exercise involves drafting a report that will be delivered at the beginning of the next tutorial. At the end, a global vote will be assigned to experimental work.The exam will be oral and will focus on the topics developed in the theoretical lessons and in the practical laboratory exercises. ASSESSMENT METHODS Written report of each laboratory exercise. Oral examination. Exam schedule Data appello Orario Luogo Degree type Note 13/04/2023 09:00 GENOVA Orale 19/06/2023 09:00 GENOVA Orale 03/07/2023 09:00 GENOVA Orale 17/07/2023 09:00 GENOVA Orale 19/09/2023 09:00 GENOVA Orale 29/01/2024 09:00 GENOVA Orale 26/02/2024 09:00 GENOVA Orale