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SINTESI DEI FARMACI (CON ESERC.)

CODE 80453
ACADEMIC YEAR 2022/2023
CREDITS
  • 5 cfu during the 5th year of 8451 CHIMICA E TECNOLOGIA FARMACEUTICHE (LM-13) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR CHIM/08
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 1° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • Pharmaceutical chemistry and technology 8451 (coorte 2018/2019)
    • GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401
    • ORGANIC CHEMISTRY I (PCT)(MD) 60822
    • ORGANIC CHEMISTRY II (PCT)(MD) 60828
    • PHARMACEUTICAL AND TOXICOLOGICAL CHEMISTRY II (PCT) 67558
    • MEDICINAL AND TOXICOLOGICAL CHEMISTRY I 80446
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The "DRUGS SYNTHESIS" Teaching program is aimed at students of the fifth year of the Single Cycle Master's Degree Course in Pharmaceutical Chemistry and Technology (CTF). The course allows the acquirement of 5 CFU and consists of a theoretical part and a practice of individual exercises in the synthesis laboratory.

    AIMS AND CONTENT

    LEARNING OUTCOMES

     

    The course aims to introduce the student to the synthesis techniques applied to the preparation of drugs.

    AIMS AND LEARNING OUTCOMES

    In particular, the student must acquire the ability to plan and implement the preparation of certain drugs by applying classic or innovative synthetic pathways (step-by-step, one pot, parallel synthesis, etc.). To apply the main isolation and purification methods of finished products from reaction mixtures, to characterize finished products through common analytical techniques. In addition, the theoretical notions concerning the synthetic methods applied, as well as the necessary and complementary activities of the synthesis (isolation, extraction, purification, anhydration, drying, etc.) will be required.

    TEACHING METHODS

    The lecturer will hold the frontal lectures in the classroom with the help of slides that will be made available to students for study at the end of each argument.
    Exercises will be introduced by a brief lesson that will be held in the classroom or in the same workshop.
    The exercises will be individual.

    SYLLABUS/CONTENT

    The course consists of theoretical lessons and practical exercises. The 5 CFUs (60 hours of frontal learning engagement per student) will be divided into 20 hours of classroom lesson and 40 hours of laboratory exercise.
    Theoretical lessons: Safety standards in the synthesis lab. The synthesis lab notebook. How to synthesize a drug. Reagents and solvents: choice, storage, use, disposal; The anhydrous solvents. Catalysts. Classic synthesis: the glassware and the main equipment used. Parallel synthesis and combinatorial synthesis: theoretical ideas and equipment. Microwave-assisted reactions: theoretical ideas and equipment. The reactions in the absence of solvent, theoretical considerations. Flow reactions, theoretical outlines and equipment. The purification techniques of reaction mixtures (solvent extraction, chromatographic separation, crystallization, distillation). The characterization of a "finished" compound: the analytical techniques used to determine structure and purity.
    Exercises
    Starting from the known drug structure, the student will be guided to plan a synthetic strategy based on the knowledge acquired in the courses of organic chemistry and pharmaceutical chemistry. In addition, the student will be able to conduct online research on specialized databases to verify the existence of known procedures in the literature that can be applied to the lab. The designed synthesis will be carried out in the laboratory and the products obtained will be purified and characterized.

    RECOMMENDED READING/BIBLIOGRAPHY

    There are no textbooks covering all the topics in a single volume and therefore the teacher prefers not to give specific indications and instead provide the tools needed by the students to find the necessary information to prepare the exam.

    The documentation required for experiments will be provided through Aulaweb or in the laboratory. Any bibliographic information relating to the applied synthesis will be obtained through appropriate research on dedicated databases (SCIFINDER, Reaxys) and by the school library system.

    TEACHERS AND EXAM BOARD

    Exam Board

    MICHELE TONELLI (President)

    SILVIA SCHENONE

    ANNA CARBONE (Substitute)

    LESSONS

    LESSONS START

    First semester of the academic year 2022/2023

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Each exercise involves drafting a report that will be delivered at the beginning of the next tutorial. At the end, a global vote will be assigned to experimental work.The exam will be oral and will focus on the topics developed in the theoretical lessons and in the practical laboratory exercises.

    ASSESSMENT METHODS

    Written report of each laboratory exercise. Oral examination.

    Exam schedule

    Date Time Location Type Notes