CODE 67617 ACADEMIC YEAR 2022/2023 CREDITS 8 cfu anno 5 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/09 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2018/2019) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2018 MATHEMATICS (PCT)(MD) 55402 2018 PHYSICS (PCT)(MD) 55404 2018 PHYSICAL CHEMISTRY (MD) 60821 2018 ORGANIC CHEMISTRY I (PCT)(MD) 60822 2018 ORGANIC CHEMISTRY II (PCT)(MD) 60828 2018 PHARMACEUTICAL TECHNOLOGY AND LAW I (PCT) 67569 2018 MEDICINAL AND TOXICOLOGICAL CHEMISTRY I 80446 2018 TEACHING MATERIALS AULAWEB OVERVIEW Applied Medicinal Chemistry is the discipline dealing with all the technological, scientific and bureaucratic aspects indispensable in order to develop and launch on the pharmaceutical market a new drug. Therefore in this course all the strategies carried out by pharmaceutical companies to optimize safety and bioavailability of the new active ingredient are exhaustively treated. AIMS AND CONTENT LEARNING OUTCOMES Providing students all the fundamental principles they need to join a team of researchers of pharmaceutical companies involved in the design and development of a new drug endowed with high therapeutic index. AIMS AND LEARNING OUTCOMES Providing students all the fundamental principles about drug discovery and development, INN and IUPAC nomenclature of organic drugs, preformulation and biopharmaceutics studies, drugs metabolism, drugs targeting and advances in pharmaceutical polymers. At the end of the Applied Medicinal Chemistry course, students will be able to: • describe the pharmaceutical industry organization • write the correct IUPAC name of an organic active pharmaceutical ingredient • link the correct International Nonproprietary Name to the therapeutic class of the active pharmaceutical ingredient • establish the best studies to define the chemical and physical properties of an active pharmaceutical ingredient • design the best chemical and/or formulation changes for an active pharmaceutical ingredient to optimize its bioavailability • identify the best strategies to improve the therapeutic index PREREQUISITES To completely understand all the topics treated in the course, students need to have already passed the following exams: medicinal and toxicological chemistry I; technique, socioeconomy and pharmaceutical legislation I TEACHING METHODS Theoretical lessons may be held online and they are aimed at simplifying the comprehension of the pharmaceutical topics treated. In this context the teacher supports particular closer examination of those topics particularly difficult to understand for students. Before starting a new lesson, to facilitate students to learn several connected chapters, a brief summing up of the previous lesson is carried out. SYLLABUS/CONTENT Drug Discovery and development INN and IUPAC nomenclature of organic drugs The development of new active ingredients Preformulation studies Biopharmaceutics Drugs metabolism Drugs targeting Macromolecules and pharmaceutics RECOMMENDED READING/BIBLIOGRAPHY A particular book to make reference to Applied Medicinal Chemistry doesn't exist. The 8 chapters of the course are composed by topics put together properly by the teacher and deriving from updated and reliable reviews in the field of applied medicinal chemistry. Each chapter is exaustively explained to students throughout the lessons and for every chapter comprehensive notes are available on Aulaweb. TEACHERS AND EXAM BOARD GIANCARLO GROSSI Ricevimento: Depending on his own professional engagements and by appointment, the teacher is always available to receive students. Exam Board GIANCARLO GROSSI (President) GABRIELE CAVIGLIOLI SARA BALDASSARI (Substitute) ELEONORA RUSSO (Substitute) CARLA VILLA (Substitute) GUENDALINA ZUCCARI (Substitute) LESSONS LESSONS START Classes usually start every year around the 20th of September with a weekly engagement of 6 hours splitted among three lessons each lasting two hours. Class schedule L'orario di tutti gli insegnamenti è consultabile all'indirizzo EasyAcademy. EXAMS EXAM DESCRIPTION The Applied Medicinal Chemistry exam may also be taken online and it is divided into two parts: the first one about drugs IUPAC nomenclature and Macromolecules in pharmaceutics is written and carried out during the course; the second one is oral and lasts about 45 minutes for each students. Questions deal with 5 topics chosen by the teacher among the subjects treated during the course. ASSESSMENT METHODS Since Applied Medicinal Chemistry Course deals with topics about the chemistry and bioavailability of most successful drugs, teacher assesses student's ability to both explain clearly all the topics treated in the course and write correctly chemical structures involved in the exam questions. Exam schedule Data Ora Luogo Degree type Note 11/04/2023 09:00 GENOVA Orale 19/06/2023 09:00 GENOVA Orale 05/07/2023 09:00 GENOVA Orale 19/07/2023 09:00 GENOVA Orale 06/09/2023 09:00 GENOVA Orale 22/01/2024 09:00 GENOVA Orale 19/02/2024 09:00 GENOVA Orale FURTHER INFORMATION Throughout the course but also before exams, depending on student's request, the teacher is available to offer additional explanations about subjects discussed during the course and considered more difficult to learn by students.