CODE 60829 ACADEMIC YEAR 2022/2023 CREDITS 8 cfu anno 2 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/09 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2021/2022) MATHEMATICS (PCT)(MD) 55402 2021 PHYSICS (PCT)(MD) 55404 2021 ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555 2021 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Pharmaceutical chemistry and technology 8451 (coorte 2021/2022) GENERAL PATHOLOGY (MD PCT) 64192 Pharmaceutical chemistry and technology 8451 (coorte 2021/2022) GENERAL PHARMACOLOGY AND TOXICOLOGY (PCT MD) 64200 TEACHING MATERIALS AULAWEB OVERVIEW The class aims at the acquisition of the understanding and knowledge of the physical, chemical, cellular and molecular mechanisms underlying the vital functions of living organisms, with specific reference to the human species and with references to an evolutionary perspective. The class is structured from the analysis of general principles at the molecular and cellular levels, to subsequently consider the interactions between cells in the organs of different systems in the performance of complex physiological functions. AIMS AND CONTENT LEARNING OUTCOMES Understanding of the general principles and common mechanisms regulating cellular functions: intercellular communication; nerve impulse propagation, synaptic transmission, sensory receptors, muscle contraction. Understanding of the mechanisms underlying the function of the major organs and systems with reference to human relational and vegetative life: blood circulation, respiration, excretion-osmoregulation, nutrition-bioenergetics; endocrinology; reproduction. AIMS AND LEARNING OUTCOMES Attendance, participation in the activities̀ offered in the classroom and individual study will aim at: - the comprehension of the common chemical and physical mechanisms regulating cellular functions; - the comprehension of the general principles underlying the functions of the organism; - the acquisition of the ability to apply the learned concepts; - the acquisition of the specific language of the discipline; - the acquisition of synthesis ability of disciplinary contents. PREREQUISITES Basic elements of Mathematics, Physics and General Chemistry. Elements of Organic Chemistry and Biochemistry, relevant for biological topics. Sufficient competence in Cell Biology and Histology for the study of the functions of cells, their molecules and of organs. Elements of Anatomy. TEACHING METHODS The class includes lectures, discussions of theoretical exercises, and supplementary support materials. SYLLABUS/CONTENT General Principles - Definition of Physiology. - Features of living beings. - Chemical composition of living matter. - Homeostasis and adaptation. Cell Physiology. - Cell membrane. Diffusion, osmosis. Membrane transport. - Cellular communication. Signal molecules, receptors. Pathways of signal transduction. - Equilibrium and diffusion potentials. Donnan equilibrium, pump and leak model, RVD, RVI. - Membrane currents and EF measurements. Action potential. - Calcium signals. Calcium homeostasis. - Synapses. Systems physiology. - Central nervous system. Brain, midbrain, cerebellum. Effector systems. - Sensory system, skin receptors. Eye, receptor retina, neural retina. Hearing. Vestibular system, taste, smell. - Endocrine system, hypothalamic-pituitary axis, epiphysis, thyroid gland. Parathyroids, calcium balance, adrenals. Glycogen metabolism. Endocrine gonads. - Muscle apparatus, striated muscle fiber, mechanics of contraction. Types of contraction, types of muscle fibers. - Body fluids, blood composition. Hemostasis, lymphatic system. Immune defense. - Cardiovascular system, electrical activity, contraction. Cardiac cycle. Vessels, flow, pressure, capillaries. Veins, pressure regulation. - Respiratory system, respiratory dynamics. Lung volumes, gas exchange, oxygen transport. Respiratory control, CO2 transport, perfusion/ventilation ratio. - Kidney, filtration absorption. Urine concentration, salt/water balance. Acid/base regulation, alkalosis, acidosis. - Digestive system, digestive glands, stomach. Liver, pancreas. Intestinal motility, absorption. - Male reproductive system. Female reproductive system, cycle. Fertilization, pregnancy. - Redox balance and energy balance RECOMMENDED READING/BIBLIOGRAPHY Recommended (alternative) handbook: Belfiore, Berteotti, Biella, Fisiologia umana. Fondamenti. Ed. Edi-Ermes D’Angelo, Peres, Fisiologia. Ed. Edi-Ermes Koeppen, Stanton, Berne e Levy Fisiologia, Ed. CEA In-depth handbooks: Conti, Fisiologia medica vol.1-2, Ed. Edi-Ermes Boron, Boulpaep, Fisiologia medica, Ed. Edra Kandel, Schwartz, Jessell, Principi di Neuroscienze, Ed. CEA More synthetic handbooks: Stanfield, Fisiologia, Ed. Edises Silverthorn, Fisiologia umana, Ed. Pearson TEACHERS AND EXAM BOARD GIORGIO GRASSELLI Ricevimento: By appointment taken via email (in person or remotely). Exam Board GIORGIO GRASSELLI (President) BRUNO PIETRO BURLANDO LESSONS LESSONS START Updated information will be posted on the AulaWeb page Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The final test will consist of an oral discussion by will aim at assessing the understanding and knowledge of the topics covered during the class, the ability to accurately present them with specific terminology, and the ability to apply the knowledge acquired will be assessed. ASSESSMENT METHODS Oral discussion Exam schedule Data appello Orario Luogo Degree type Note 20/06/2023 09:00 GENOVA Orale 04/07/2023 09:00 GENOVA Orale 18/07/2023 09:00 GENOVA Orale 05/09/2023 09:00 GENOVA Orale 19/09/2023 09:00 GENOVA Orale 30/01/2024 09:00 GENOVA Orale 13/02/2024 09:00 GENOVA Orale OpenBadge PRO3 - Soft skills - Alfabetica base 1 - A PRO3 - Soft skills - Personale base 1 - A PRO3 - Soft skills - Sociale base 1 - A PRO3 - Soft skills - Imparare a imparare base 1 - A