LEARNING OUTCOMES

To know the metabolic pathways and the relationships among by anabolic and catabolic pathway. To know the elements of base of absorption and  elimination of the drug and their mechanism of actionTo know the metabolic pathways and the relationships among by anabolic and catabolic pathway. To know the elements of base of absorption and  elimination of the drug and their mechanism of action

AIMS AND LEARNING OUTCOMES

To acquire the basic concepts of Pharmacokinetic. The knowledge will be specifically in demand: the mechanisms that regulate the absorption of the drugs, with respect in the route of administration; the distribution, the metabolism and the elimination of the drugs. To identify the characteristics of the principal pharmaceutical forms related to the administration of the therapy (oral, intramuscular, intravenous..). To know the main pharmacokinetic parameters and their clinical meaning. To know the main aspects of Pharmacodynamics; the concepts of tolerance, intolerance, therapeutic index and their clinical aspects. To understand the glossary of the Summary of product characteristics ('SmPC')  of the drugs and their interpretation. To know the use of some classes of agents which are used in the treatment of infectious diseases, with particular regard to therapeutic appropriateness, the assessments of adverse reactions of antibiotic, antiviral and antifungal agents.

To acquire The basic concepts on A.N.S. active drugs.

To acquire the capability of drug doses computation (oral and paretheral administration)

TEACHING METHODS

The frontal lessons are held with the aid of slides that are made available to all the students on Aulaweb. Particular attention will be focused on the solution of exercises of drug doses computation.

SYLLABUS/CONTENT

• General principles of pharmakinetic: absorption (with particular respect to routes of drug administration); distribution, metabolism and elimination of the drugs

• Main pharmacokinetic parameters and their clinical meaning

• Hints of pharmacodynamics: tolerance, intolerance and therapeutic index

• Exercises of calculation

• Antibiotic therapy: appropriateness, therapeutic uses, evaluation of the adverse reactions

• Hints of antiviral therapy

• Hints of antifungal therapy

• Overview of anatomy and physiology and basic concepts on A.N.S. active drugs

RECOMMENDED READING/BIBLIOGRAPHY

“Farmacologia per le professioni sanitarie”  Anita Conforti, ecc. Ed. Idelson Gnocchi;

" Le basi della farmacologia" R D Howland, M J Mycek. Ed. Zanichelli - Calcoli e dosaggi farmacologici. G. Le Donne, S. Tolomeo. Ed. Casa Editrice Ambrosiana

TESTI INTEGRATIVI CONSIGLIATI:  Diagnosi e Terapia Pediatrica Pratica. V. Maglietta. Casa Editrice Ambrosiana