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PHARMACOLOGY

CODE 67210
ACADEMIC YEAR 2022/2023
CREDITS
  • 6 cfu during the 3nd year of 8746 ODONTOIATRIA E PROTESI DENTARIA (LM-46) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/14
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    PREREQUISITES
    Prerequisites
    You can take the exam for this unit if you passed the following exam(s):
    • School of Dental Medicine 8746 (coorte 2020/2021)
    • EXPERIMENTAL PATHOLOGY 62662
    Prerequisites (for future units)
    This unit is a prerequisite for:
    • School of Dental Medicine 8746 (coorte 2020/2021)
    • MEDICAL SCIENCES II 67223
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    Pharmacology is the science which study the interactions between drugs and the organisms. It includes the study of the origin and structure of the drugs, the mechanisms of their action, pharmacokinetics, their clinical use, their side effects and toxicity.

    AIMS AND CONTENT

    LEARNING OUTCOMES

    Didactic goal will be the acquisition of the basic pharmacological knowledge to be able to prescribe and administer the drugs of common use during the odontoiatric practice, focusing on composition, mechanism of action, pharmacokinetics, clinical use, side effects, toxicity, and interactions. Moreover, effects, contraindications and interactions of other drugs commonly used in internal medicine, should be known as possible interferents with the common odontoiatric procedures.

    AIMS AND LEARNING OUTCOMES

    At the end of the course the student should be:

    -Know the main bases of pharmacokinetics and pharmacodynamics

    -Know mechanisms of action, route of administration, distribution and elimination of the main drugs used during odontoiatric procedures (i.e. NSAIDs, local anesthetics, antibiotics, etc.), their toxicity and the main interaction with other internistic drugs

    TEACHING METHODS

    Teaching of pharmacology will be performed by frontal lessons, Total CFU are 6 (60 hours)

    SYLLABUS/CONTENT

    1) Introduction to the study of pharmacology (definition of drug, toxicant); pharmaceutical preparations, development of new drugs (preclinical and clinical experimentation); pharmacognosy

    2) Route of administration of the drugs; bioavailability; drug absorption and physico-chemical requirements to cross bio-membranes. First pass metabolism.

     3) Drug distribution and VAD, protein binding; phase I and II drug metabolism

    4) Renal and extra renal drug elimination; 1 and 0 order kinetics; clearance, steady state.

    5) Pharmacodynamics: drug-receptor interaction; agonists; competitive and non-competitive antagonists; partial agonist; inverse agonists. Definition and significance of potency and efficacy. Therapeutic index; up- and down regulation of the receptors;

    6) structure and functioning of the main types of receptors, ion channels, and pharmacologically relevant enzymes. Signal transduction;

    7) Adverse drug reactions; pharmaco-allergy, idiosyncrasy, tolerance. Factors at the basis of the individual differences in the drug action.

    8) Adrenergic neurotransmission and pharmacological modulation

    9) Cholinergic neurotransmission and pharmacological modulation

    10) Benzodiazepines: mechanism of action, clinical use, toxicity; compounds Z

    11) Pharmacology of nociception and opiates

    12) NSAIDs

    13) Glucocorticoids

    14) Local anesthetics and association with sympathomimetic amines; general anesthetics; N2O

    15) General concepts of antibiotic-therapy; misuse and resistance

    16) Beta-lactams (penicillin G, and p semisynthetic penicillins) beta-lactamase inhibitors

    17) Cephalosporines. carbapenemes, monobactamic. Glycopeptides

    18)   Macrolides

    19) Fluorochinolones

    20) Second choice antibiotics; antiseptics

    Drug prescription in Italy

    21) Aminoglycosides, tetracyclines, CAF

    22) Antiviral drugs

    23) Antifungines

    24) Drugs affecting calcium metabolism

    25) antagonists of H1 and H2 receptors

    26) Antiplatelet and anticoagulant drugs

    27) Drugs used for emergency

    RECOMMENDED READING/BIBLIOGRAPHY

    All the slides shown during the frontal lessons will be made available to the students on the Aulaweb site.

    All the pharmacology textbooks for Dentistry are suitable to integrate the lessons (i.e. Farmacologia in odontoiatria di Matilde Amico Roxas, UTET editore)

    TEACHERS AND EXAM BOARD

    Exam Board

    TULLIO FLORIO (President)

    FEDERICA BARBIERI

    LESSONS

    LESSONS START

    Second semester

    Class schedule

    PHARMACOLOGY

    EXAMS

    EXAM DESCRIPTION

    The exam of pharmacology will be performed as an interview, focusing on the topics discussed during tke lessons

    ASSESSMENT METHODS

    The student will have to demonstrate knowlege of the mechanisms involved in the reciprocal interactions between the body and the drugs (pharmacodinamics and pharmacokinetics); the mechanism of action, the clinical use, the side effects and the possible drug interactions of the main pharmacological classes described during the course.

    Exam schedule

    Date Time Location Type Notes
    23/01/2023 09:00 GENOVA Orale L'esame si svolgerà presso l'ex Istituto di Farmacologia, viale Benedetto XV numero 2
    09/02/2023 09:00 GENOVA Orale L'esame si svolgerà presso l'ex Istituto di Farmacologia, viale Benedetto XV numero 2
    27/02/2023 09:00 GENOVA Orale L'esame si svolgerà presso l'ex Istituto di Farmacologia, viale Benedetto XV numero 2