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BIOCHEMICAL PROPAEDEUTICS

CODE 57730
ACADEMIC YEAR 2022/2023
CREDITS
  • 3 cfu during the 1st year of 8744 SCIENZE MOTORIE, SPORT E SALUTE (L-22) - SAVONA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/10
    TEACHING LOCATION
  • SAVONA
  • SEMESTER 1° Semester
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The Propaedeutics Biochemistry teaching gives students a basic knowledge of chemistry and biochemistry, necessary for learning the main notions of Biochemistry.

    AIMS AND LEARNING OUTCOMES

    At the end of the course the student knows:

    • the basic concepts of the chemistry with particular reference to the concepts of kinetic and chemical thermodynamics.

    • the general concepts of organic chemistry and reactivity of functional groups

    • the aqueous solutions and the calculation of the pH of acids and bases

    • structure and reactivity of biomolecules

    TEACHING METHODS

    Frontal lessons . Lectures in the classroom are delivered through multimedia presentations.

     

    SYLLABUS/CONTENT

    Chemical nomenclature

    Number of oxidation. basic and acidic oxides. Hydroxides. Acids. inorganic salts

    The biomolecules

    Chemical composition (C, H, O, N, S, P). chemical bonds and chemical interactions (electrostatic, van der Waals forces, hydrogen bonding, hydrophobic bonding). polarity concept. Electronegativity. Three-dimensional structure. Isomers and isomeric configuration and conformation.

    Organic Chemistry

    Functional groups of organic chemistry and biomolecules. Functional group  of organic chemistry Structures. Principal reactions of functional groups. Polyfunctional compounds.

    Chemical reactivity.

    The reactions that occur in the cells. Reactions of oxidation-reduction, carbon-carbon bonds, groups transfer reactions, condensation and hydrolysis reactions, isomerization reactions, synthesis reactions. Examples applicable to biochemistry (biochemical redox)

    Chemical kinetics. chemical balance. Equilibrium constant. Le Chatelier's principle .Rate of reaction. Factors which limit the rate of reaction. Catalysis and catalysts.

    Bioenergetics.

    Thermodynamics and metabolism. I and II law of thermodynamics. Spontaneity of a reaction. Enthalpy, entropy, standard free energy. Free energy. Standard free energy. Free energy and equilibrium constant.

    Water.

    Structure. Weak interactions in aqueous environment. Water as solvent and as reactant. Amphoteric properties of water. Ionization of water. Colligative properties of aqueous solutions.

    Properties of aqueous solutions.

    pH concept. Acids and bases. Strength of acids and bases. Ka and Kb. Conjugated acids and bases. Calculation of pH for weak and strong acids and bases. Buffer solutions. The biological buffers.

    Optical isomerism.

    Carbon chiral and optical isomerism. Configurations D and L.

    Carbohydrates.

    Monosaccharides, disaccharides, polysaccharides and their structures. Glycosidic bonds.

    Lipids.

    Classification of lipids Saturated and unsaturated fats. Acylglycerols. Phospholipids. Waxes ,Terpenes and steroids.

    Amino acids and proteins.

    Amino acid structure. The side chains of amino acids. Peptide bond.

    Nucleotides.

    Nitrogen bases. Nucleosides and nucleotides. ATP. Nucleotides present in coenzymes.

     

    RECOMMENDED READING/BIBLIOGRAPHY

    Santaniello - Alberghina - Coletta - Marini Principi di chimica generale e organica Editore Piccin

    Luciano Binaglia, Bruno Giardina Chimica e propedeutica biochimica Editore  Mc Graw-Hill.

    Stefani, M., Taddei, N. Chimica Biochimica e Biologia Applicata Editore Zanichelli.

    Roberti R., Bistocchi G.A., Elementi di Chimica e Biochimica Editore McGraw-Hill

    NELSON David L , COX Michael M INTRODUZIONE ALLA BIOCHIMICA DI LEHNINGER Editore Zanichelli.

    TEACHERS AND EXAM BOARD

    LESSONS

    LESSONS START

    first quarter in October 2022

    EXAMS

    EXAM DESCRIPTION

    oral examination

    ASSESSMENT METHODS

     

    The oral examination will focus mainly on the topics covered during the lectures and will have the purpose to evaluate not only if the student has reached an adequate level of knowledge, but if he has acquired the ability to critically analyze problems that will be made during the examination. The student will also be asked to draw the structure of biomolecules, identifying the types of reaction involved. Finally it will comeassessed the ability to describe chemical processes with appropriate terminology.

    Exam schedule

    Date Time Location Type Notes
    11/01/2023 09:00 GENOVA Orale
    02/02/2023 09:00 GENOVA Orale
    16/02/2023 09:00 GENOVA Orale
    01/06/2023 09:00 GENOVA Orale
    26/06/2023 09:00 GENOVA Orale
    24/07/2023 09:00 GENOVA Orale
    22/09/2023 09:00 GENOVA Orale

    FURTHER INFORMATION

     

    Regular attendance at lectures is strongly recommended