|SCIENTIFIC DISCIPLINARY SECTOR||MED/04|
You can take the exam for this unit if you passed the following exam(s):
The course aims to provide the student with basic knowledge (molecular, genetic and cellular) to interpret the fundamental mechanisms of cell damage and defense of the organism.
Aim of the Course is to provide the student with basic knowledge (at molecular and cellular levels) for understanding the fundamental mechanisms of cell response to damage. A relevant part of the course is focused on the defense mechanisms toward a "stressor" stimulus and how this triggers cell/tissue/organ morpho-functional alterations. These issues are well addressed by learning of inflammatory and immunological responses, closely related to each other. Particular attention will be given to the natural and acquired mechanisms of the inflammatory and immune process against bacterial and viral pathogens, the organization of the immune system, the involved different cells, the mechanisms of antigen recognition, the differentiation and activation of B and T lymphocytes, the development of their effector responses. Moreover the mechanisms underlying the tolerance towards its constituents and the main immune mechanisms of pathological relevance will be explained.
The teaching aims to provide students
At the end of the course, the student will be able to
Prerequisites: notions of Cytology, Histology, Physiology, Biochemistry, Molecular Biology, Developmental Biology.
The teaching activity is carried out through lectures with the aid of on-screen presentations. The teaching material is available in pdf version on Teams or aulaweb, to allow the student to learn and deepen the topics indicated in the course program and required for passing the final exam.
In case of changes in the health and epidemiological situation, the lessons will be held at a distance (Teams).
There are no student reception hours, but students can contact the teachers by email in order to make an appointment for further explanations.
• BIOLOGICAL HOMEOSTASIS: state of health, concept of injury, sign, symptom and disease. Cell damage mechanisms. Aging.
• Notes on extrinsic causes of disease: chemical, physical and biological causes
• CELL RESPONSE TO DAMAGE: reversible damage, persistent damage - adaptation (atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia); irreversible damage: cell death (necrosis, apoptosis). Role of heat shock proteins in the response to damage and in the control of cell functions and the response to misfolded proteins (UPR).
• PRINCIPLES OF ROOT PATHOLOGY: reactive oxygen and nitrogen species: biological actions and involvement in cell damage.
• INNATE IMMUNITY: cells and molecules, local and systemic inflammation, acute and chronic, histological variants of inflammation with examples of pathologies
• ADAPTATIVE IMMUNITY: generation, education and functions of B and T lymphocytes
• PATHOLOGIES OF THE IMMUNE SYSTEM: type I hypersensitivity and notes on immunodeficiencies, autoimmunity and auto-inflammatory diseases with some examples of pathologies
• HEMOPOYESIS, HEMOPOIETIC STEM CELL (HSC) AND BONE MARROW TRANSPLANT
• ATHEROSCLEROSIS and notes on ischemic heart disease
LABORATORY: theoretical-practical applications of basic methods suitable for the in vitro evaluation of the cytotoxic potential of compounds (e.g. MTT assay, Alamar Blue), setting up of dynamic in vitro systems with the use of millifluidic bioreactors, preparation of cell lysates on which to perform protein dosage and dedicated seminars.
• Robbins and Cotran: The pathological basis of diseases (Elsevier)
• Abbas, Lichtman: Cellular and Molecular Immunology (Elsevier)
Students with SLD, disability or other special educational needs certification are strongly encouraged to contact the teachers at the beginning of the course to agree on teaching methods which, respecting the teaching objectives, take into account individual learning methods and provide suitable compensatory instruments.
Office hours: By appointment Cristina.Bottino@unige.it
Office hours: Reception by appointment: firstname.lastname@example.org
CRISTINA BOTTINO (President)
STEFANIA VERNAZZA (President Substitute)
The end-of-course exam aims to assess the achievement of the educational objectives of the course. The exams take place on the dates indicated in the calendar. Verification is oral, in person, conducted by two teachers for each student. The grade is assigned as a weighted average.
The teachers verify the achievement of the educational objectives by asking diversified questions relating to the programs actually carried out during the lesson hours. When the educational objectives have not been achieved, the student is invited to better verify his knowledge and to take the exam again in its entirety.
In case of changes in the sanitary and epidemiological situation, the exams will be carried out remotely (TEAMS).
Examination Committee: Proff. Cristina Bottino, Stefania Vernazza
Verification of learning takes place only through the final exam which aims to verify the actual acquisition, by the student, of the expected learning outcomes. In order to pass the exam, with a score of not less than 18/30, the student must demonstrate that they know and connect the topics covered during the course
The following contribute to the final mark expressed out of thirty:
- Ability to deal with the requested topics in a transversal and critical manner;
- Correctness, clarity, synthesis and fluidity of presentation;
- Mastery of the subject;
- Adoption of appropriate terminology
The mark of 30/30 with possible honors will be awarded when the knowledge / skills of the subject are excellent.
Students with SLD or other regularly certified special educational needs will be able to agree on written or oral modalities with the teacher, by contacting the teachers at least 10 days before the exam. They can also take advantage of 30% additional time.
|21/12/2022||14:00||GENOVA||Orale||Preappello riservato SOLO ed ESCLUSIVAMENTE agli studenti iscritti al 3 e 4 anno. Devono essere rispettate le propedeuticità dell'anno di iscrizione a medicina Gli studenti che non soddisfano i criteri di cui sopra non potranno sostenere l'esame SEDE ESAME: Aula 3 - Edificio 6 - Polo didattico Alberti L'elenco degli studenti con data e ora dell'esame sarà pubblicato sul team delle lezioni|
|09/01/2023||09:00||GENOVA||Orale||SEDE ESAME: Auletta patologia generale|
|16/01/2023||09:00||GENOVA||Orale||SEDE VESAME: Auletta Patologia Generale, Edificio 7 (ex patologia generale) - piano Terra, via L.B. Alberti 2|
|30/01/2023||09:00||GENOVA||Orale||SEDE ESAME: Aula grande di patologia Generale|
|06/02/2023||09:00||GENOVA||Orale||SEDE: Biblioteca, Istituto di patologia generale, primo piano NB: gli studenti che non hanno sostenuto gli esami propedeutici NON potranno sostenere l'esame di PATOLOGIA GENERALE IMMUNOLOGIA E LABORATORIO|
|20/02/2023||14:00||GENOVA||Orale||Gli studenti di odontoiatria sosterranno l'esame lunedì, ore 14.30, biblioteca di patologia Per gli studenti di medicina gli esami inizieranno mercoledì 22 febbraio (lettera estratta F). L'elenco degli studenti con data, ora e sede dell'esame è disponibile sul canale teams bw6jvck. Eventuali scambi 1:1 tra gli studenti devono essere comunicati in sede d'esame Nel caso del superamento di prove propedeutiche a fisiopatologia e non ancora registrate in carriera, gli studenti devono presentare una dichiarazione firmata dal docente|
|06/04/2023||09:00||GENOVA||Orale||Appello straordinario riservato a studenti IN CORSO CON OBBLIGO DI FREQUENZA iscritti al 3 o 4 anno di medicina SEDE: Aula 5 - Edificio 6 - Polo didattico Alberti ore 9.30 ANTONINI ALESSIO 4683504 API ANNA 4821940 BARBAGELATA BEATRICE 5000733 BONVICINO VALENTINA 5103177 BRAMBILLA FEDERICO 4932480 CARONI JUAN DAVIDE 4825108 COSTA ALESSANDRA 4834799 DE MORO FRANCESCA 4805704 DEL GAUDIO DENISE 5102220 FADDA FEDERICA 5005464 FOTSO KENGNE WILFRIED BORIS 4799742 GHISILIERI JORGE MANUEL 4820169 GRANDIS ALBERTO 4327798 ore 14.30 KHALIFA NORHAN 4371368 MARSANO NICOLÒ 5107137 ORSOLINO VIOLA 5017234 PANINA CHIARA 4815231 PASQUALI SUSANNA 5102451 PIASTRI FRANCESCA 5000744 PIETRAFRACCIA CHIARA EMMA 4822336 PROSERPIO CHIARA 5103111 RISSO VIRGINIA 4943819 RIVA ANNALISA 5109315 SQUERI CAROLA 4624929 TARÌ ALICE 5115277 VEGLIO VALENTINA 5017971 VINCI GIADA 5102439|
|16/05/2023||09:00||GENOVA||Orale||Appello riservato a studenti fuoricorso o ripetenti senza obbligo di frequenza SEDE: Auletta Patologia generale|
|05/06/2023||14:30||GENOVA||Orale||SEDE auletta chirurgica ORARIO h 14.30|
|13/06/2023||14:00||GENOVA||Orale||il preappello è riservato UNICAMENTE agli studenti che intendono presentare domanda di tesi il 14 giugno. Gli iscritti dovranno firmare un'auto certificazione che attesta il diritto di partecipare all'appello|
Attendance allows the student to better learn the contents of the course because the teacher provides detailed explanations during the lessons and frames the topics with continuous references to the most current discoveries in the field of the subject. The teaching material is available online (Teams or Aulaweb)