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## ANALYSIS OF BIOMEDICAL DATA AND SIGNALS

CODE 80563 2022/2023 9 cfu during the 1st year of 11159 BIOENGINEERING(LM-21) - GENOVA ING-INF/06 English GENOVA 1° Semester AULAWEB

## OVERVIEW

Provides the basic notions for data and signal analysis and practical applications to biomedical data and signals.

## AIMS AND CONTENT

### LEARNING OUTCOMES

L'insegnamento fornisce gli strumenti essenziali e le competenze operative per l’analisi quantitativa di dati e segnali di interesse per la medicina e la biologia, in una prospettiva probabilistica

### AIMS AND LEARNING OUTCOMES

The aim of this course is to provide students with the essential tools for quantitative analysis of data and signals of interest for medicine and biology.

By the end of the course the students will be able to:

1. Design and apply methods of analysis and modelling of data - including temporal data (signals) - of interest for medicine and biology

2. Identify the correct approach (model selection, model identification, data visualization) for a specific data analysis problem

3. Use MATLAB to correctly and effectively visualizing biomedical data and signals and to implement models of them

### PREREQUISITES

There are no formal prerequisites, but  the course requires solid foundations in mathematical analysis and linear algebra.

### TEACHING METHODS

The course is organised as a combination of lectures and lab activities.

Lectures will focus on theory and methods for data analysis.

Lab activities will focus on application to real data analysis problems in the context of bioengineering.

In AY 2022-2023 the course will be taught in presence.

### SYLLABUS/CONTENT

A. Data Analysis and Data Display (wk 1-2)
Data types. Descriptive statistics. Analysis as modeling. Statistical data analysis. Regressione. Visual display of information.

B.Probability density estimates (wk 3-4)
Unsupervised learning. Gaussian model. Principal Component Analysis, FactorAnalysis, Independent Component Analysis, Cluster analysis and the EM algorithm. Graphical models. Regression, decision theory, factor analysis as graphical models.

C. Pattern analysis and decision theory (wk 5-6)
Bayesian decision theory. Bayes classifiers. Logistic classifiers. Performance of a classifier: ROC curve. Generalized linear models. Introduction to neural networks.

D. Model selection (wk 7-8). Statistical Inference. Hypothesis testing. General Linear models and the analysis of variance. Mixed-effects models. Bayesian modelselection.

E. Dynamic Models (wk 9-10). Temporal data (signals). Discrete vs continuoussignals. Hidden Markov Models, Linear dynamical systems. Kalman filter.

F. System identification (wk 11-12)Parametric vs nonparametric models. Black-box vs grey-box models. Least square estimators. Prediction error methods. Compartmental models. Application to pharmakinetics and epidemiology .

Murphy, KP. Machine Learning: A Probabilistic Perspective.  MIT Press, 2012.

## TEACHERS AND EXAM BOARD

### Exam Board

VITTORIO SANGUINETI (President)

MAURO GIACOMINI

MARCO MASSIMO FATO (President Substitute)

## LESSONS

### LESSONS START

https://corsi.unige.it/11159/p/studenti-orario

### Class schedule

All class schedules are posted on the EasyAcademy portal.

## EXAMS

### EXAM DESCRIPTION

Written exam (weight 50%)

Project work (individuals or couples, weight 50%)

• Solution of a real problem of biomedical data analysis/processing, chosen from a list of proposed projects

• Development of software for calculation/analysis/processing

• Interactive application (MATLAB Livescript) reporting the results

### ASSESSMENT METHODS

Project work will be assessed in terms of:

1) Documentation (correctess, clarity, synthesis, terminology): 10 pts

2) Implementation (code structure and organization, efficiency): 10 pts

3) Data Visualization (technical quality of figures, adequacy of display technique, efficacy, clarity): 10 pts

4) Bonus (max  2 pts) if the report provides additional analysis (in addition to those required). Bonus is only awarded if maximum score is obtained in the other three criteria.

### Exam schedule

Date Time Location Type Notes
11/01/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3
26/01/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3
09/02/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3
08/06/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3
06/07/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3
07/09/2023 09:30 GENOVA Scritto 12 Jan 2022 h930 Room E3 10 Feb 2022 h930 Room E3