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CODE 67362
ACADEMIC YEAR 2023/2024
CREDITS
SCIENTIFIC DISCIPLINARY SECTOR MED/04
LANGUAGE Italian
TEACHING LOCATION
  • GENOVA
SEMESTER 1° Semester
PREREQUISITES
Propedeuticità in ingresso
Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami:
Propedeuticità in uscita
Questo insegnamento è propedeutico per gli insegnamenti:
  • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
  • GENERAL PHYSIOPATHOLOGY 67362 2021
  • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
  • GENERAL PHYSIOPATHOLOGY 67362 2021
  • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
  • GENERAL PHYSIOPATHOLOGY 67362 2021
  • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
  • GENERAL PHYSIOPATHOLOGY 67362 2021
  • MEDICINE AND SURGERY 8745 (coorte 2021/2022)
  • GENERAL PHYSIOPATHOLOGY 67362 2021
TEACHING MATERIALS AULAWEB

OVERVIEW

The course gives students the fundamental elements of pathophysiology, which are essential for the successive comprehension of clinical medical sciences.

AIMS AND CONTENT

LEARNING OUTCOMES

Physiopathology is a branch of medicine that combines physiology and pathology especially in the study of altered bodily function in disease. The learning outcome is the knowledge of the main physiopathological mechanisms of organs and systems,  in order to recognize the mechanisms and causes of their malfunction, and to be able to interpret the symptoms, which will be exposed to the students in the successive clinical courses

AIMS AND LEARNING OUTCOMES

Knowledge of the main physiopathological mechanisms of organs and systems, with particular regard to blood, liver, kidney, respiratory and digestive systems, some aspects of endocrinology and metabolism, and the physiopathology of neoplasms.

PREREQUISITES

basic knowledge in anatomy, histology, biochemistry, immunology, physiology and general pathology

TEACHING METHODS

Lectures, with any possible dialectic interaction with students

In case of sanitary emergency, lessons will switch to remote learning

SYLLABUS/CONTENT

Hematopoiesis

The hematopoietic and mesenchymal stem cells

Bone marrow transplant / HSC

Erythropoiesis

Anemias. Classification and general considerations

Bone marrow aplasia

B12 and folate deficiency anemia

Thalassemia, Iron deficiency anemia

Auto and alloimmune hemolytic anemias

Paroxysmal nocturnal hemoglobinuria

Hemostasis and bleeding diathesis

Abnormalities of the vascular wall, thrombocytopenia

Alterations of clotting factors

The neoplastic transformation; benign and malignant tumors; metastasis

Local and systemic effects, paraneoplastic syndromes

Molecular basis of cancer

Oncogenes and related neoplastic diseases

Oncosuppressors and related neoplastic diseases

Epidemiology

Risk and prognostic factors, stage, grade

Cancer stem cells (CSCs)

Hematological neoplasms: classification and general considerations

Myeloid neoplasms

Lymphoid neoplasms

Angiogenesis and tumor microenvironment

Anti-tumor immune response

Neoplasm and inflammation

Atherosclerosis

Ischemic heart disease

Rheumatic fever

Hypertension

Heart failure

 

 

Renal physiopathology and acute and chronic renal insufficiency and failure.

Salts and water balance (in particular water, sodium and potassium balances)

Acid-base equilibrium: overview and analysis of respiratory and metabolic disorders of the acid-base balance. Simple and mixed disorders.

Diabetes mellitus and its acute and chronic complications

Dyslipidemias: lipoprotein metabolism, Fredrickson classification, primary and secondary causes of dyslipidemia.

Some examples of alterations of nitrogen metabolism

 

Thrombosis and Thrombotic Risk

Embolism

Shock: general features and causes

Hypovolemic, Cardiac and Neurogenic Shock

Respiratory System Pathophysiology

Acute and chronic respiratory insufficiencies

Hypoxia, anoxia, cyanosis

COPD and pulmonary emphysema

General characteristics of bronchial asthma

Immunopathology of pulmonary fibrosis

Gastrointestinal system pathophysiology

Main gut pathologies

Immune-mediated intestinal diseases

Liver and biliary tract pathophysiology

Etiopathogenesis of hepatitis, NAFLD, NASH, cirrhosis, hepatocarcinogenesis

Causes of jaundice

Pathophysiology of the immune response

RECOMMENDED READING/BIBLIOGRAPHY

Robbins & Cotran Pathologic Basis of Disease, Elsevier

Altucci L. et al, Patologia generale, Ed. Idelson Gnocchi

The didactic material is available in pdf format for download (aulaweb).

The aim of the course is also to familiarize students with online biomedical scientific literature (https://www.ncbi.nlm.nih.gov/pubmed)

Students with SLD, disability or other special educational needs certification are strongly encouraged to contact the teachers at the beginning of the course to agree on teaching methods which, respecting the teaching objectives, take into account individual learning methods and provide suitable compensatory instruments.

TEACHERS AND EXAM BOARD

Exam Board

CRISTINA BOTTINO (President)

GUIDO FERLAZZO (President)

NICOLA TRAVERSO (President)

LESSONS

LESSONS START

1st semester, 3rd year

Class schedule

L'orario di tutti gli insegnamenti è consultabile all'indirizzo EasyAcademy.

EXAMS

EXAM DESCRIPTION

The end-of-course exam aims to evaluate the achievement of the educational objectives of the course. The exams take place on the dates indicated in the calendar. Verification is oral, conducted by two teachers for each student. The grade is assigned as a weighted average. The teachers verify the achievement of the educational objectives by asking diversified questions relating to the programs actually carried out during the lesson hours. When the educational objectives have not been achieved, the student is invited to better verify his knowledge and to take the exam again in its entirety. There are no student reception hours, but students can contact the teachers by email in order to make an appointment for further explanations.

Exam Commission: Proff. Cristina Bottino, Nicola traverso, Guido Ferlazzo

 

ASSESSMENT METHODS

Verification of learning takes place only through the final exam which aims to verify the actual acquisition, by the student, of the expected learning outcomes. In order to pass the exam, with a score of not less than 18/30, the student must demonstrate that they know and connect the topics covered during the course

The following contribute to the final mark expressed out of thirty:

- Ability to deal with the requested topics in a transversal and critical manner;

- Correctness, clarity, synthesis and fluidity of presentation;

- Mastery of the subject;

- Adoption of appropriate terminology

The mark of 30/30 with possible honors will be awarded when the knowledge / skills of the subject are excellent.

Students with SLD or other regularly certified special educational needs will be able to agree on written or oral modalities with the teacher, by contacting the teachers at least 10 days before the exam. They can also take advantage of 30% additional time.

 

Exam schedule

Data Ora Luogo Degree type Note
15/12/2023 09:00 GENOVA Orale Appello straordinario riservato esclusivamente agli studenti frequentanti il 4 anno La commissione sarà composta da Bottino, Traverso e Domenicotti Le domande verteranno sul programma svolto a lezione nell'aa 22/23 SEDE: Auletta patologia generale
19/12/2023 09:00 GENOVA Orale Riservato esclusivamente a studenti che frequentano il 3 anno SEDE: Aula Anfiteatro di Anatomia Patologica Lettera estratta: F L'elenco degli iscritti con data e ora dell'esame è disponibile sul TEAM MEDICINA-FISIOPATOLOGIA 2023 - codice 0q43ibv
09/01/2024 09:00 GENOVA Orale Aula 7, Polo Alberti
30/01/2024 09:00 GENOVA Orale Aula 3, polo Alberti ________________________________________________ ODONTOIATRIA ORE 9 AMINI ERFAN 5167351 MALEKIMEIGHANI MEHRDAD 4603854 NAKHAEI SOBHAN 4637789 ______________________________________________ MEDICINA: Lettera estratta: H ORE 9 ______________________________________ HASHEM MAHMOUD 5012383 JAKOB MARVIN 4678818 KRUJA DANIELA 3919875 MACCHI ELISA 5103144 NARDONE ANDREA 5120666 OTTONELLO MARTA 3816662 PANETTA MATILDE AURORA 5254701 PANZERI DAVIDE ENRICO 5362974 PATINI CAROLA 4813118 PAVEL VIOLETA ANTOANELA 4899468 PO DARIO 5232866 REVELLI PIETRO 4904089 REVELLO GIULIA 5178197 SALA ELENA 4475176 SALAMON CARLOTTA 4558183 SANTAGOSTINO-BARBONE FEDERICO 5365010 STELLA LORENZO GIOVANNI 5381003 STOLFO IRENE 4991076 TONNA ELISA 5374096 TRAVERSONE ALESSANDRO 4840925 ORE 15 ________________________________________________ ARANGIO FRANCESCA 5115046 BENEDETTO SOFIA 5212594 BERCHI MANUELA 2320847 BERTELLA AGNESE 5017663 BORTONE SIMONE 5317314 BRACCI BENEDETTA 5369784 CARMAGNANI ELISA 5370311 CATALDO FRANCESCA 4034120 DELLEPIANE GIULIA 4859220 DI SPIGNO NICOLA 5277461 FARCHIONI FRANCESCO 5363678 FERO VIOLA 5365339 FERRARO CATERINA 5132272 GARRUBBA ERICA 4634038 GHEORGHIU MIHAIL FELIX 5126617 GIBELLI LUCA 5224836 GUMA ADA 3412905
20/02/2024 09:00 GENOVA Orale Aula 2, Polo didattico Alberti Lettera estratta C ___________________________________________________ MEDICINA ORE 9 CADENASSO GAIA 5204696 CAPPELLETTI * AURORA 4339205 CARMAGNANI ELISA 5370311 CARVAJAL VICTORIA 5391080 CATALDO * FRANCESCA 4034120 CRUCITTA ELEONORA 5016541 DI GIORGIO BARBARA PIA 5383214 DI STEFANO GIOVANNI 5371466 DONATO MICHELA 4991373 FERO VIOLA 5365339 INGLESE MELANIA 5660195 JAKOB MARVIN 4678818 KRUJA DANIELA 3919875 LATTANZIO * LAURA 5207974 MACCHI ELISA 5103144 MARZELLA FIAMMETTA 4732301 MAURO NICCOLÒ 4824954 MERLO BEATRICE 5235726 MICHELINI RICCARDO MARIO 5221460 MOCHI FRANCESCO 5010974 mancano propedeuticità ____________________________________________________ MEDICINA ORE 14.30 NARDONE ANDREA 5120666 PEPAJ * MARIA 4902999 PISATI CESARE 4733335 POLLASTRI GIULIA 5362479 QUINSON * SOPHIE 4893406 REVELLI PIETRO 4904089 RIZZO CATERINA 5021149 ROCCA SABRINA 4842817 SALAMON CARLOTTA 4558183 SANNA* FRANCESCA 5370519 SANTAGOSTINO-BARBONE FEDERICO 5365010 STOLFO IRENE 4991076 TELESCA ANDREA RUBEN 3876271 VERDOIA * ANDREA SILVIO 5230776 ZAHER FATIMA 5150366 ZENEVRE LUDOVICA 5096806 ADASSERY KATHRYN 5231777 BAGLIANI ALONZO NICHOLAS 4976929 BASSANINI REBECCA 5371763 BERCHI MANUELA 2320847 BERTELLA AGNESE 5017663 BIESTRO * ANDREA 5365625 BONORA VIRGINIA 5030059 BORTONE SIMONE 5317314 BOZANO CAMILLA 5019236 BULGHERONI ASIA 5362590 BUZZO * VALENTINA 4865247 * mancano propedeuticità ______________________________________________________ ODONTOIATRIA ore 9 AMINI ERFAN 5167351 DELDADEH * HAMIDREZA 4850353 GJINAJ JONKA 4513423 MALEKIMEIGHANI MEHRDAD 4603854 NAKHAEI SOBHAN 4637789 WEHBI ZAHRA 5214749 * mancano propedeuticità
29/04/2024 09:00 GENOVA Orale APPELLO APERTO A TUTTI (purchè provvisti delle opportune propedeuticità)
15/05/2024 09:00 GENOVA Orale RISERVATO UNICAMENTE A STUDENTI FUORICORSO O RIPETENTI SENZA OBBLIGO DI FREQUENZA
04/06/2024 09:00 GENOVA Orale
25/06/2024 09:00 GENOVA Orale
17/07/2024 09:00 GENOVA Orale
03/09/2024 09:00 GENOVA Orale
17/09/2024 09:00 GENOVA Orale

FURTHER INFORMATION

Attendance allows the student to better learn the contents of the course because the teacher provides detailed explanations during the lessons and frames the topics with continuous references to the most current discoveries in the field of the subject. The teaching material is available online (Aulaweb)