CODE 80445 ACADEMIC YEAR 2023/2024 CREDITS 8 cfu anno 3 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/08 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2021/2022) GENERAL AND INORGANIC CHEMISTRY (PHAR)(MD) 55413 2021 ORGANIC CHEMISTRY 60795 2021 DRUGS ANALYSIS I 80443 2021 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Pharmaceutical chemistry and technology 8451 (coorte 2021/2022) INSTRUMENTAL ANALYSIS OF DRUGS (WITH PRACTICE) 80452 TEACHING MATERIALS AULAWEB OVERVIEW The "Analysis of drugs II" course is aimed at third year students of the Single Cycle Master's Degree Course in Pharmaceutical Chemistry and Technology (CTF). The course allows the acquirement of 8 credits and consists of theoretical lessons and practical exercises in the laboratory. AIMS AND CONTENT LEARNING OUTCOMES The course deals with the separation of mixtures and the purification of organic substances of pharmaceutical interest, using different methods including chromatography, distillation or crystallization. The isolated substances are subsequently identified through classical qualitative analysis, based on the research of the elements and on the identification of functional groups present in the molecules, followed by the determination of some physical constants, such as melting or boiling point, density, optical rotation. The theoretical lessons are accompanied by practical exercises. AIMS AND LEARNING OUTCOMES The student will have to acquire the ability to plan and implement qualitative analysis and characterization procedures for identifying drugs or compounds of pharmaceutical interest, featured by an inorganic and organic nature. TEACHING METHODS The teacher will hold the lectures in the classroom with the help of slides that will be made available to students at the end of each topic. Exercises will be introduced by a short illustrative lesson that will be held in the classroom or in the laboratory. The exercises will be individual. SYLLABUS/CONTENT The course of 8 CFU (96 hrs of commitment in frontal teaching activity per student) is divided into two parts: a theoretical one, consisting of 32 hours of lessons, and a practical one, which includes 64 hours of individual exercises in the laboratory. The practical exercises performed in the laboratory are carried out in close correlation with the topics of the course, as indicated in the following program. Syllabus: Chemistry Laboratory Safety Rules. Laboratory risk prevention. Inorganic qualitative analysis for the characterization of inorganic drugs and associated impurities. Assay in bunsen flame and in crucible. Systematic search for the anions of groups I-IV. Systematic search for cations of groups I-VI. Organic qualitative analysis based on the research of the elements and on the identification of functional groups present in compounds of pharmaceutical interest. Preliminary tests: organoleptic test, combustion test, organic elemental analysis, solubility, identification tests. Functional group analysis. Determination of some physical constants, such as melting or boiling point, density, refractive index, optical rotation. RECOMMENDED READING/BIBLIOGRAPHY F. Savelli, O. Bruno, Analisi chimico farmaceutica – Ed. Piccin V. Cavrini, V. Andrisano, Principi di analisi farmaceutica – Ed. Esculapio TEACHERS AND EXAM BOARD MICHELE TONELLI Ricevimento: From Monday to Friday, by appointment (via e-mail or telephone). Exam Board MICHELE TONELLI (President) ANNA CARBONE CHIARA BRULLO (Substitute) ELENA CICHERO (Substitute) VALERIA FRANCESCONI (Substitute) FRANCESCA MICHELA MUSUMECI (Substitute) SILVIA SCHENONE (Substitute) LESSONS LESSONS START Second semester of the academic year 2022/2023 Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The exam will be oral and will focus on the topics developed in the theoretical lessons and in the practical laboratory exercises. ASSESSMENT METHODS Written report of each laboratory exercise. Oral examination. Exam schedule Data appello Orario Luogo Degree type Note 04/04/2024 09:00 GENOVA Orale 20/06/2024 09:00 GENOVA Orale 04/07/2024 09:00 GENOVA Orale 18/07/2024 09:00 GENOVA Orale 12/09/2024 09:00 GENOVA Orale 23/01/2025 09:00 GENOVA Orale 18/02/2025 09:00 GENOVA Orale