CODE 80481 ACADEMIC YEAR 2023/2024 CREDITS 2 cfu anno 4 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA 2 cfu anno 3 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR CHIM/08 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: OPTIONAL SUBJECTS (PCT MD) III YEAR TEACHING MATERIALS AULAWEB AIMS AND CONTENT AIMS AND LEARNING OUTCOMES The course aims to provide a basic understanding about the medicinal chemistry strategies as well as the computational methods exploring the pharmacodynamic and pharmacokinetic profile of drug candidates TEACHING METHODS The course is developed with theoretical and practical lessons (16 hours). SYLLABUS/CONTENT Rational design of hit compounds Medicinal chemistry methods to optimize the pharmacodinamic and pharmacokinetic profile of drug candidates. Computational methods to manage in silico drugs and biological targets. Homology modeling and molecular docking techniques. QSAR analyses and pharmacophore searching methods. Virtual screening and molecular dynamic simulations: case studies. In silico evaluation of the bioavailability and safety profile of drugs. RECOMMENDED READING/BIBLIOGRAPHY Introduzione alla Chimica Farmaceutica, Seconda Edizione – Graham L. Patrick, EDISES Manuale di Chimica Farmaceutica- Progettazione, meccanismo d’azione e metabolismo dei farmaci, Richard B. Silverman, Mark W. Holladay - EDRA Chimica Farmaceutica-I processi di scoperta dei farmaci, Erland Stevens-PICCIN Principi di Chimica Farmaceutica, Thomas L. Lemke, S. William Zito, Victoria F. Roche, David A. Williams - PICCIN TEACHERS AND EXAM BOARD ELENA CICHERO Ricevimento: From Monday to Friday, by email appointment Exam Board BRUNO TASSO (President) ELEONORA RUSSO (President Substitute) LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral test. ASSESSMENT METHODS The examination includes an oral test and an evaluation of the student acquired ownership of the main medicinal chemistry and computational strategies applied for the search of new drugs.
