CODE 64200 ACADEMIC YEAR 2024/2025 CREDITS 8 cfu anno CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA 8 cfu anno 3 CHIMICA E TECNOLOGIA FARMACEUTICHE 8451 (LM-13) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/14 TEACHING LOCATION GENOVA SEMESTER 2° Semester PREREQUISITES Propedeuticità in ingresso Per sostenere l'esame di questo insegnamento è necessario aver sostenuto i seguenti esami: Pharmaceutical chemistry and technology 8451 (coorte 2022/2023) GENERAL AND INORGANIC CHEMISTRY (PCT)(MD) 55401 2022 MATHEMATICS (PCT)(MD) 55402 2022 PHYSICS (PCT)(MD) 55404 2022 ORGANIC CHEMISTRY I (PCT)(MD) 60822 2022 ORGANIC CHEMISTRY II (PCT)(MD) 60828 2022 GENERAL PHYSIOLOGY (PCT)MD) 60829 2022 ANIMAL BIOLOGY AND HUMAN ANATOMY (I.C.)(PCT MD) 64555 2022 BIOCHEMISTRY AND APPLIED BIOCHEMISTRY (I.C.)(PCT MD) 80520 2022 Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: Pharmaceutical chemistry and technology 8451 (coorte 2022/2023) PHARMACOLOGY AND PHARMACOTHERAPY (PCT) 67563 TEACHING MATERIALS AULAWEB OVERVIEW The course is transformed by combining with the molecular biology module. The interest for biotechnological drugs will be characterized by in-depth studies and dedicated lessons. The course is aimed at providing the bases of pharmacology and toxicology. Moreover, will be provided knowledge and tools related to scientific research in this field. AIMS AND CONTENT LEARNING OUTCOMES The course of Pharmacology aims to provide knowledge about the general mechanisms of drug interactions with the biological structures. The course will deal from a qualitative and quantitative point of view: the interactions of drugs with receptors and other proteins the mechanisms of drug absorption, distribution, metabolism, and elimination. the individual variability of the drug response the toxicity of a drug the mechanisms of drug interactions AIMS AND LEARNING OUTCOMES The goal is to create a solid foundation for dealing with the management of the drug. The student will learn what a pharmacological problem means, analyze the efficacy and safety of a drug and evaluate specific cases related to the emerging development of biotechnological drugs PREREQUISITES General chemistry and inorganic Organic chemical I. Organic chemical II. Biochemistry and applied biochemistry Animal biology and human anatomy Maths Physics General Physiology TEACHING METHODS Frontal lectures or, if necessary, in telematic teaching mode. Any Student with documented Specific Learning Disorders (SLD), or with any special needs, shall reach out to the Lecturer(s) and to the dedicated SLD Representative in the Department ( Prof. Luca Raiteri, Luca.Raiteri@unige.it ) before class begins, in order to liaise and arrange the specific learning methods and ensure proper achievement of the learning aims and outcomes. VERY IMPORTANT: any request for compensatory tools and adaptations in the exam MUST be done within 10 working days before the date of the exam according to the instructions that can be found at https://unige.it/disabilita-dsa/comunicazioni SYLLABUS/CONTENT 1. General Pharmacology and Toxicology 2. Pharmacodynamics 3. Pharmacokinetics (PK) 4. Challenges in Pharmacological Research 5. Receptors 6. Ionotropic Rs (IRs) 7. Metabotropic R Metabotropy (MRs) 8. IRs Main families, localization, activities 9. MRs Main families, localization, activities 10. Other receptors 11. Carrier (T) 12. T Main families, localization, activities 13. Non-functional Techniques 14. Functional Techniques 15. Drug-Receptor interaction (FR) 16. Pharmacological Theories 17. FR Constants and parameters 18. FR Linear and logarithmic graphic representations 19. Computer software and tools 20. Allosteric and orthosteric ligands 21. Absorption 22. Distribution 23. Metabolism 24. Elimination 25. PK In the elderly 26. PK In the smoker 27. PK In the cannabis consumer 28. PK in the obesity 29. Routes of administration 30. Ways of elimination 31. Metabolism's Phases, genetic variations and processes 32. PK Parameters and kinetics 33. Toxicology 34. Drugs Handling 35. Preclinical, and clinical trials 36. Toxicity test 37. Mechanisms of Toxicity 38. ADR and Pharmacovigilance 39. Forensic toxicology 40. Contrast liquids 41 Vaccines and biotechnological drugs RECOMMENDED READING/BIBLIOGRAPHY Goodman & Gilman Le basi farmacologiche della terapia Zanichelli Hitner & Nagle Principi di Farmacologia Zanichelli Katzung, Master, Trevor Frmacologia Generale e clinica Piccin Casarett & Doull Elementi di tossicologia Casa editrice Ambrosiana Tossicologia generale e applicata ai farmaci- Manzo, Paolillo e Vitalone -edra Il meccanismo d'azione dei farmaci Francesco Clementi Guido Fumagalli-edra Rossi, Cuomo, Riccardi Farmacologia principi di base e applicazioni terapeutiche V ed Edizioni Minerva Medica LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral examination ASSESSMENT METHODS The learning outcomes will be based on the assessment during the examination of three key aspects: appropriateness of the terminology skills and notions reasoning ability Exam schedule Data appello Orario Luogo Degree type Note 18/06/2025 09:30 GENOVA Orale 18/06/2025 09:30 GENOVA Orale 02/07/2025 09:30 GENOVA Orale 02/07/2025 09:30 GENOVA Orale 16/07/2025 09:30 GENOVA Orale 16/07/2025 09:30 GENOVA Orale 04/09/2025 09:30 GENOVA Orale 04/09/2025 09:30 GENOVA Orale 18/09/2025 09:30 GENOVA Orale 18/09/2025 09:30 GENOVA Orale 19/01/2026 09:30 GENOVA Orale 19/01/2026 09:30 GENOVA Orale 05/02/2026 09:30 GENOVA Orale 05/02/2026 09:30 GENOVA Orale