CODE 101082 ACADEMIC YEAR 2024/2025 CREDITS 2 cfu anno 1 TECNICHE DELLA PREVENZIONE NELL'AMBIENTE E NEI LUOGH 9298 (L/SNT4) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 2° Semester MODULES Questo insegnamento è un modulo di: GENERAL PATHOLOGY AND TOXICOLOGY TEACHING MATERIALS AULAWEB AIMS AND CONTENT AIMS AND LEARNING OUTCOMES The main aim of General Pathology teaching is to provide students with basic knowledge on the following topics: i) causes of human diseases, ii) cell and tissue damage,iii) tissue response to damage (inflammation and repair) and iv) neoplastic disease. At the end of the course, students will be able to classify the causes of human diseases; recognize the adaptation responses to damage; classify inflammatory processes; describe the atypia of the tumor cell; acquire basic medical terminology to describe the pathological processes taken into consideration. TEACHING METHODS The teaching is organized in frontal lessons for a total of 20 hours. Lessons are given by the teacher with the help of presentations that are made available to students on the web classroom. In periods of health emergency, lessons are held remotely using the TEAMS platform and are recorded by the teacher. SYLLABUS/CONTENT INTRODUCTION. Fields of interest of General Pathology. Homeostasis concept. Definition of morbid phenomenon, morbid process, morbid state and disease. GENERAL ETIOLOGY. Causes of human diseases. Intrinsic causes. Gene, genomic and chromosomal mutations. Notes on congenital malformations. Concept of aplasia, agenesis and hypoplasia. Embriopathies and fetopathies. Extrinsic causes of a physical nature. Radiation: classification based on nature (corpuscular and electromagnetic) and biological effect (ionizing and exciting). Direct and indirect effects of radiation. Burns (and their general consequences) and frostbite. General concepts on heatstroke and frostbite. Extrinsic causes of a mechanical nature: trauma of superficial tissues. Trauma of the internal organs. Osteoarticular trauma. Concepts of regeneration and repair. Wound healing by first and second intention. Extrinsic causes of a thermal nature: burns and frostbite. Extrinsic chemical causes: alteration of pH (acids and bases), solvent action, denaturing action and toxic action. Defenses against poisons. Congenital and acquired defenses. CELLULAR PATHOLOGY. Cell damage and death: necrosis and apoptosis. Damage adaptation responses. Atrophy. Hypertrophy and hyperplasia. Notes on the alterations of differentiation: metaplasia, dysplasia and anaplasia. Examples of degenerative diseases. INFLAMMATORY RESPONSE AND IMMUNITY. Definition, causes, and phases of the inflammatory response. Classification of acute inflammations: serous, fibrinous, mucous, purulent, hemorrhagic, necrotic, allergic. Chronic inflammation: characters and cells of the chronic inflammatory infiltrate. Classification of chronic inflammations: interstitial and granulomatous. Immunological and non-immunological granulomas. Specific immunity. Humoral factors and cellular factors. Antigen concept. Maturation and activation of B and T lymphocytes. Immunoglobulins. CANCERS. Definition of neoplasia: concepts of autonomy, afinalism and progression. Morphological atypia, biochemical and behavioral atypia. Metastases: definition, ways of metastasis, concept of organotropism. Molecular basis of tumors: oncogenes and tumor suppressors. Causes of tumors. Concept of initiation and promotion. Physical and chemical carcinogenic agents. Viral carcinogenesis. Classification of tumors: classification by behavior (benign and malignant); classification by histogenesis (epithelial and connective tissue tumors); classification by gradation and staging (TNM system). RECOMMENDED READING/BIBLIOGRAPHY Rubin E. and Reisner HM Patologia Generale-L'essenziale -Ediz Piccin-Vol. 1 G.M. Pontieri Patologia Generale, Edizioni Piccin Lecture notes will be available on Aulaweb. TEACHERS AND EXAM BOARD MARIAPAOLA NITTI Ricevimento: Anytime by appointment CINZIA MARIA DOMENICOTTI Ricevimento: The reception of the students is agreed from time to time, according to the needs and deadlines, by e-mail to the following address: Cinzia.Domenicotti@unige.it The office is located at General Pathology Section - DIMES via LB Alberti 2- Genoa tel +39 010 3538830 Exam Board MARIAPAOLA NITTI (President) PAOLA MODESTO STEFANO THELLUNG DE COURTELARY VINCENZO TROVATO CINZIA MARIA DOMENICOTTI (President and Coordinator of Integrated Course) LESSONS LESSONS START Lessons start in the second semester in early March. Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The exam consists of an oral test. ASSESSMENT METHODS The oral exam will focus on the discussion of some topics concerning the program carried out through which the teacher will verify if the student has achieved the learning outcomes. The ability to present, synthesize and critically analyze the contents of the program will also be assessed. Exam schedule Data appello Orario Luogo Degree type Note 14/01/2025 09:30 GENOVA Orale L’esame sarà martedì 14 gennaio 2025 nell’aula B, DISSAL, via Pastore 1, a partire dalle 9.30. 11/02/2025 09:30 GENOVA Orale nell’auletta di Patologia Generale, piano terra, entrata da via LB Alberti 2 10/06/2025 09:30 GENOVA Orale 04/07/2025 09:30 GENOVA Orale 25/07/2025 09:30 GENOVA Orale 03/09/2025 09:30 GENOVA Orale 24/09/2025 09:30 GENOVA Orale