The course deals with specific classes of drugs: antimicrobials, antiprotozoals and antivirals. The principles of antitumor chemotherapy and chemotherapeutic drugs are also covered. Finally, drugs derived from hormones and vitamins are described. The structural and kinetic characteristics and modes of action of each class of compounds are detailed and examples of synthesis of the main drugs are reported, so that the student can have a complete overview of these families of therapeutic agents.
The focus of the course is to discuss the modes of action, the structure-activity relationships, the pharmacodynamic and pharmacokinetic profiles and the synthetic methodologies of various classes of anti-infective and anti-tumour chemotherapeutic agents currently used in the clinical practice.
At the end of the course the student will master the theoretical knowledge to:
In-person classes for a total of 40 hours.
Any Student with documented Specific Learning Disorders (SLD), or with any special needs, shall reach out to the Lecturer(s) and to the dedicated SLD Representative in the Department ( Prof. Luca Raiteri, Luca.Raiteri@unige.it ) before class begins, in order to liaise and arrange the specific learning methods and ensure proper achievement of the learning aims and outcomes. VERY IMPORTANT: any request for compensatory tools and adaptations in the exam MUST be done within 10 working days before the date of the exam according to the instructions that can be found at https://unige.it/disabilita-dsa/comunicazioni
The slides are available in aulweb website.
The pharmacodynamics/pharmacokinetics properties of the different classes of drugs will be discussed highlighting the structure-activity relationships and the synthetic procedures for their preparation. In detail:
1. Antiseptics and disinfectants
2. Sulfonamides
3. Antibiotics
4. Quinolones
5. Nitrofuran compounds
6. Oxazolidinones
7. Antimycobacterial chemotherapeutics
8. Antifungal chemotherapeutics: polyenes (amphotericin B), imidazole and triazole azoles. Allyl- and benzylamines. Thiocarbamates. Morpholines. Echinocandins.
9. Antiprotozoal chemotherapeutics
10. Anthelmintics
11. Antivirals
12. Antitumor agents
13. Peptide hormones
14. Steroid hormones
15. Diagnostic and therapeutic radiopharmaceuticals
Foye's. Principi di chimica farmaceutica. Piccin
Wilson & Gisvold. Chimica Farmaceutica. Casa Editrice Ambrosiana
Gasco, Gualtieri, Melchiorre. Chimica farmaceutica. Casa Editrice Ambrosiana
Costantino, Sbardella. Chimica farmaceutica. Edises
Ricevimento: The students can email the professor and set a meeting
According to academic calendar available at https://corsi.unige.it/corsi/11673/studenti-orario
The timetable for this course is available here: EasyAcademy
The exam includes an oral interview (in presence, about 45 minutes long) concerning the topics covered during the lessons.
The exam will be considered passed if the student obtains a grade equal to or greater than 18/30.
The oral exam aims to evaluate the student's preparation in terms of:
For further information, please contact the professor.