OVERVIEW

The Clinical Pathology III course deals with biological assays and laboratory blood tests characteristic of organ and bone marrow transplantation and autoimmune diseases.

AIMS AND CONTENT

LEARNING OUTCOMES

Aim of the course is to provide the principles underlie to a) organ and hematopoietic stem cell transplantation, b) main features of autoimmune diseases. This aim focusing on in vitro assays to evaluate donor-recipient compatibility and biological parameters indicating: graft rejection and GVHD, diagnosis and progression of  autoimmune disease.

TEACHING METHODS

Classroom-taught lectures, queries and replies on the next lesson, problem-based learning

SYLLABUS/CONTENT

Organ and bone marrow transplantation, markers of transplant rejection, graft versus host disease (GVHD), methods to assess donor-recipient compatibility, methods to assess biological parameters during graft rejection and GVHD, basic principle of auto-reactivity, autoimmunity and autoimmune diseases, organ specific autoimmune diseases, autoimmune hepatitis, systemic autoimmune diseases, systemic lupus erythematosus, methods to assess biological parameters and diagnose autoimmune diseases.

RECOMMENDED READING/BIBLIOGRAPHY

Lectures notes will be made available to all students via Aulaweb. Some topic can be further analyzed on the following text references:Roitt's Essential Immunology, 13th Editiondi Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt; ISBN: 978-1-118-41577-1, 576 pages, January 2017,Wiley-Blackwell; and on the site: http://www.roitt.com/; Janeway’sImmunobiologyEdition: 9th Author(s): Kenneth Murphy, Casey Weaver, Garland Science editor ISBN:9780815345053 Publication Date:March 28, 2016 Content Details: 904 pages | 621 illustrations, Language: English. Hematology, Basic Principles and Practice, Expert Consult Authors: Ronald Hoffman Edward Benz Leslie Silberstein Helen Heslop Jeffrey WeitzJohn Anastasi, Hardcover ISBN: 9781437729283, eBook ISBN: 9781455740413 Imprint: Churchill Livingstone, Published Date: 19th November 2012, Page Count: 2384

TEACHERS AND EXAM BOARD

Exam Board

OTTAVIA BARBIERI

paolo CARLIER

ALESSANDRO POGGI

NICOLA TRAVERSO (President and Coordinator of Integrated Course)

LESSONS

LESSONS START

March 2018

EXAMS

EXAM DESCRIPTION

Oral exam. The student will be examined answering three queries on procedures and biological parameters relevant in pathological/clinical conditions that are subject of the course. The examination will be passed if the student knows and is able to assess which biological parameters should be studied in those pathological/clinical conditions.

ASSESSMENT METHODS

Oral

Exam schedule