he lessons contained in the course of General Pathology and Immunology are intended to provide a biotechnology student with a general picture of the defense methods implemented by our immune system against etiologic agents and neoplasms. The course also analyzes the pathogenetic mechanisms of inflammatory response and neoplastic transformation.
Knowledge of the main mechanisms underlying the inflammatory process and the neoplastic transformation. In-depth knowledge of the main molecular and cellular mechanisms of the immune response (natural and adaptive) against pathogens and tumors. Knowledge of hypersensitivity reactions and related conditions.
The part of General Pathology gives in-depth knowledge on the inflammatory process The concepts of angioflogosis and histoflogosis will be defined and characterized. Important aspects of general oncology will be addressed, such as the definitions of oncogene, tumor marker and metastasis. The classification of tumors on the basis of behavior, histogenesis, grading and staging will be defined.
About Immunology, the physiology of the immune system and the peculiar feature of innate and adaptive immune response will be deeply characterized. Finally, some of the principal pathological aspects of immune system will be described.
MOLECULAR PATHOLOGY
- The inflammatory process
Definition and causes of angioflogosis
Active and passive hyperemia: causes and consequences
Inflammatory oedema: causes and different exudates
Cellular and plasmatic mediators
Histoflogosis: pathogenesis and classification
Tissue repair
Hints on tuberculosis and syphilis
-General oncology
Modern definition of neoplasia
Cancer cells: atypical morphology, metabolism and behavior
Main concepts of tumor marker
Initiation, promotion and progression in carcinogenesis
Metastasis: definition and implications of tumor spread
Oncogenes: definition of and their mechanisms of activation
Hints on genetic predisposition to cancer
Causes of cancer: physical, chemical and biological factors
Classification of tumors on the basis of: behavior (malignant/benign), histogenesis, grading and staging
IMMUNOLOGY
The Immune System: Cells and Tissues of the Immune System.
General features of the Innate and Adaptive Immune response.
The Innate Immunity Receptors. The Complement System.
Natural Killer Cells (NK). Dendritic Cells (Myeloid and Plasmacitoid).
The Adaptive Immune Response. Clonal selection Theory.
Origin and maturation of T and B lymphocytes. The Antigen receptors gene rearrangement (Immunoglobulin and T Cell receptors)
The Major Histocompatibility Complex (MHC) . The antigen processing and presentation to T Lymphocytes.
Activation of T Lymphocytes. Effector mechanisms of Cell mediated Immunity. Cytotoxic and Helper T cells subpopulations
B cell activation and Antibody production. The effector mechanisms of Humoral Immunity
The Cytokines.
Immunity to Pathogens. Mucosal Immunity. The Hypersensitivity Reactions. The immunity to tumors
Molecular Pathology: G.M. Pontieri, Elementi di patologia generale per i corsi di Laurea in Professioni Sanitarie. III Edizione PICCIN.
Immunology: P.Parham, Il sistema Immunitario, EdiSes; AK Abbas, AH Lichtmann, Le basi dell’Immunologia, ELSEVIER.
Ricevimento: By appointment by email: mariacristina.mingari@unige.it
Ricevimento: By appointment by email: ricciarelli@medicina.unige.it
Ricevimento: By appointment by email: gabriella.pietra@unige.it
MARIA CRISTINA MINGARI (President)
GABRIELLA PIATTI (President)
GABRIELLA PIETRA (President)
ROBERTA RICCIARELLI (President)
