OVERVIEW

The Course is meant to give an understanding of the main causes of disease and knowledge of the physiological response to cell and tissue damage. The Course gives also insights into the pathogenesis of important processes such as inflammation, neoplastic transformation, metabolic and blood related disorders

AIMS AND CONTENT

LEARNING OUTCOMES

Knowledge of different aspects of general physiopathology that enable graduate students to explore or expand any field connected to this topic.

AIMS AND LEARNING OUTCOMES

Understanding of the mechanisms underlying the inflammatory process and the neoplastic transformation. In-depth knowledge of the main molecular and cellular mechanisms of the immune response (natural and adaptive). Comprehension of the central aspects of important metabolic and blood diseases.

The Course is intended to allow a thorough grounding and a multi-perspective approach to principles of physiopathology.

TEACHING METHODS

Frontal lessons

SYLLABUS/CONTENT

Environmental causes of disease: causes of physical origin (Radiations and Temperature) and different kinds of trauma; causes of chemical origin.

- Mechanisms of xenobiotic biotransformation.

- General features of the innate and adaptive immune response.

- The inflammatory process: definition and causes of angioflogosis; active and passive hyperemia          (causes and consequences), the inflammatory oedema (causes and different exudates), cellular and   plasmatic mediators, histoflogosis (pathogenesis and classification).

- Mechanisms of tissue repair.

- Pathological regressive processes: atrophy, degeneration and cell death.

- Pathological progressive processes: hypertrophy/hyrperplasia, metaplasia and neoplasia.

- General oncology: atypical morphology, metabolism and behavior of cancer cells; initiation,     promotion and progression in carcinogenesis; metastasis (definition and implications of tumor     spread); oncogenes (definition of and their mechanisms of activation); causes of cancer (physical,     chemical and biological factors); classification of tumors on the basis of behavior         (malignant/benign), histogenesis, grading and staging.

RECOMMENDED READING/BIBLIOGRAPHY

 Patologia generale: 1) GM Pontieri, Elementi di Patologia generale, Piccin, 2) M. Parola, Patologia Generale, EdiSes

TEACHERS AND EXAM BOARD

Exam Board

TULLIO FLORIO (President)

FRANCESCA MATTIOLI

MARIA ADELAIDE PRONZATO (President and Coordinator of Integrated Course)

LESSONS

LESSONS START

Lessons will start in October month

Class schedule

EXPERIMENTAL PATHOLOGY

EXAMS

EXAM DESCRIPTION

The students  will have oral examinations

ASSESSMENT METHODS

The students must know the basic elements of General Pathology

Exam schedule