The Clinical Pathology III course deals with biological assays and laboratory blood tests characteristic of organ and bone marrow transplantation and autoimmune diseases.
Aim of the course is to provide the principles underlie to a) organ and hematopoietic stem cell transplantation, b) main features of autoimmune diseases. This aim focusing on in vitro assays to evaluate donor-recipient compatibility and biological parameters indicating: graft rejection and GVHD, diagnosis and progression of autoimmune disease.
The main aim of the course is to describe and analyze in detail a) the molecular mechanisms underliyng the graft versus host compatibility in organ or hematopoietic stem cells graft; b) the laboratory methods applied to determine this compatibility and the biochemical/molecular features of incompatibility reactions after the organ or hematopoietic stem cells graft (i.e. graft versus host disease and graft reaction); c) pathogenetic mechanims of systemic and organ specific autoimmune diseases; d) umoral and cellular parameters altered in autoimmune diseases.
The student has a) to know the reason why there is the graft versus host incompatibility, graft versus host reaction or graft rejection; b) to identify the methods applied to evaluate biological parameters during the above mentioned reactions; c) to know the serum parameters and the methods to evaluate these parameters during systemic and organ specific autoimmune diseases; d) to identify on the basis of a specific parameter the autoimmune disease and in which phase, among those analyzed in the program, may be present.
Classroom-taught lectures, queries and replies on the next lesson, problem-based learning
Organ and bone marrow transplantation, markers of transplant rejection, graft versus host disease (GVHD), methods to assess donor-recipient compatibility, methods to assess biological parameters during graft rejection and GVHD, basic principle of auto-reactivity, autoimmunity and autoimmune diseases, organ specific autoimmune diseases, autoimmune hepatitis, celiac disease, systemic autoimmune diseases, systemic lupus erythematosus, methods to assess biological parameters and diagnose autoimmune diseases.
Ricevimento: Students can book an appointment with the professor usually by professor's email (alessandro.poggi@hsanmartino.it) and students will agree on date and time.
paolo CARLIER
ANNALISA FURFARO
ALESSANDRO POGGI
NICOLA TRAVERSO (President and Coordinator of Integrated Course)
March 2019
Oral exam.
The student will be examined answering three queries on procedures and biological parameters relevant in pathological/clinical conditions that are subject of the course. The examination will be passed if the student knows and is able to assess which biological parameters should be studied in those pathological/clinical conditions.
