CODE 68163 ACADEMIC YEAR 2018/2019 CREDITS 1 cfu anno 2 TECNICHE DI LABORATORIO BIOMEDICO 9293 (L/SNT3) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: GENERAL PATHOLOGY, PHYSIOPATHOLOGY, IMMUNOLOGY AND PARASITOLOGY TEACHING MATERIALS AULAWEB OVERVIEW Immunology is the science that studies the immune system, an integrated set of molecules and cells that operate in a coordinated manner to maintain the homeostasis of the organism and protect it from external agents, such pathogens and their products. The course also will address the main changes that affect the immune-mediated disease mechanisms. Finally, we will be introduced to the principles of immunological techniques for the application in quantitative and diagnostic analysis. AIMS AND CONTENT LEARNING OUTCOMES The purpose is to educate the knowledge of the structural and molecular mechanisms responsible for immune recognition of the signs of infection and damage to the tissues; to know the phenotypic and functional characteristics of the major immune cell populations responsible for the various stages of immune responses to injury; to know the mechanisms of integration and regulation of the answers themselves and learn the signaling mechanisms and the main pathways of signal transduction; to learn the main pathophysiological mechanisms underlying the alterations of the immune response. AIMS AND LEARNING OUTCOMES The student will have to learn the methods of recognition and response operated by the different cell types of the human immune system and understand the relationships cause / effect at the base of the main alterations in the functioning of the immune system. The course ultimately the goal of framing the principles of immunological techniques used in clinical research and diagnostic laboratories. TEACHING METHODS The course includes 10 hours of lectures through the use of slides. SYLLABUS/CONTENT Features of the immune system The primary and secondary lymphoid organs: Bone Marrow and Timo (structure and characteristics), spleen and lymph nodes, the Associated Lymphoid Tissue mucosa (MALT) The immune cells: a) features and functions of innate immunity cells (granulocytes, monocytes and macrophages, natural killer) ; b) features and functions of T and B lymphocytes Innate Immune Response (natural) and specific (acquired): main features and phases of the immune response. The complement (signs) Hypothesis of clonal selection (signs). Maturation of lymphocytes T and B. The antigen receptor of T and B lymphocytes Antigens: general characteristics and definition of epitope. Antibodies: structure and function of antibodies, antibody classes. The antigens of the major histocompatibility system class I and II (MHC): structure and function Processing and presentation of antigens to T lymphocytes Immune cell-mediated and humoral responses. Activation and differentiation of T and B lymphocytes Cytokines and chemokines: their role in the immune response The immune response to pathogens Antigen-antibody reaction ( precipitation, agglutination, hemagglutination, complement fixation, immunoenzymatic reactions, reactions radioimmunoassay, immunofluorescence) IMMUNOPATHOLOGY Hypersensitivity reactions: classification and general features. Autoimmunity: organ-specific autoimmune diseases and systemic (signs) Primary immunodeficiency diseases (signs). Secondary or acquired immunodeficiencies: AIDS. (signs) RECOMMENDED READING/BIBLIOGRAPHY Le difese immunitarie di Guido Forni,Elena Quaglino,Federica Cavallo. Editore: PICCIN-NUOVA LIBRARIA TOOLS IN SUPPORT OF TEACHING: Copy of slides projected in class TEACHERS AND EXAM BOARD DANIELA FENOGLIO Ricevimento: The interview with the teacher can be obtained by email (daniela.fenoglio@unige.it) or by phone (010 / 3533027-3029). The teacher's studio is located in the Directorate of the Centre of Excellence for Biomedical Research (CEBR) - Viale Benedetto XV, 7 -16132 Genova Exam Board DANIELA FENOGLIO MARIA ADELAIDE PRONZATO (President and Coordinator of Integrated Course) LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION Oral ASSESSMENT METHODS The aim of the examination is to test the level of knowledge and depth of the topics covered in the course by a final oral examination. During the interview, the student must demonstrate knowledge of the meaning of the terms used in the immunological field, to understand the fundamental mechanisms at the cellular and molecular level of the immune system and its regulation; to learn the basics of immunological techniques. Exam schedule Data appello Orario Luogo Degree type Note 14/01/2019 09:00 GENOVA Orale 11/02/2019 09:00 GENOVA Orale 14/06/2019 09:00 GENOVA Orale 05/07/2019 09:00 GENOVA Orale 22/07/2019 09:00 GENOVA Orale 11/09/2019 09:00 GENOVA Orale 27/09/2019 09:00 GENOVA Orale FURTHER INFORMATION Final vote