The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science. These approaches can be all included in the term "Combinatorial chemistry"
As combinatorial chemistry was introduced as a synthetic strategy in the drug discovery process, the first part of the course will mainly focus on organic chemistry aspects. In the second part of the course the extension of the combinatorial approach to material science will be illustrated.
The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.
The student at the end of the course will be able to:
-use search engines to find -in the relevant literature- combinatorial applications in all fields of material science
-collect articles and critically analyze them, for what concerns the combinatorial approaches which have been used
-design a simple combinatorial experiment to prepare libraries of materials
-individuate general analytical techniques needed to carachterize the libraries
Lectures, bibliographic search through serching engines, powerpoint presentations
Soluble and insoluble polymers. Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports. Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods. Combinatorial chemistry: use and applications. Parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests. Combinatorial chemistry and material science. Literature search
“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3
“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6
Ricevimento: on appointment
The exam consists of two parts
The first part is a presentation/discussion of an article, recently published in the relevant literature, dealing with a specific combinatorial chemistry application.
The second part is an oral examination where the student will be asked general questions related to the course program
The students will be asked to prepare a powerpoint presentation on a specific subject, chosen in agreement with the teacher. The student will present the work in front of the classroom and the evaluation will be mainly on four aspects
1. the clarity of the exposition; 2. the clarity of the powerpoint presentation; 3. the competence on the specific subject; 4. the capability to answer to questions
The second part of the exam will be an oral examination where general questions on the course matter will be asked. With the oral examination it will be possible to assess the competence of the students on the general principles of combinatorial chemistry and on the specific subject of solid-phase synthesis
