Food Toxicology is a science that helps us understand the harmful effects of food contaminants and additives can have on human. Toxicology tries to know and identify the dose and through what mechanism the substances are hazard
The main objective of Food Toxicology is to provide knowledge regarding the toxicological aspects related to food. Students will critically learn topics related to food toxicology. The interactions between xenobiotics and humans and the consequent onset of toxic effects will be discussed. Some toxicity tests and methods for toxicological risk assessment will be illustrated. The main toxicity factors and molecule targets of toxic agents, as well as the most recurrent toxicity mechanisms and organ toxicity, will be explored. The toxicological implications of the food adulteration or the presence of pesticide od durg residues, environmental pollutants or natural contaminants will be discussed too.
The course in Food Toxicology aims to provide the basic knowledge of toxicology to explain the mechanisms of toxic agents underlying toxicological evets according to the modern toxicology. At the end of the course the students must know the toxicokinetic properties (time-action) of the xenobiotics, including the kinetic of absorption, distribution, metabolism and excretion, demonstrating that they have understood the dynamic principles of the action of chemicals, including dose - response curves, biochemical and physiological effects of xenobiotics and their molecular mechanisms. The students will also have to demonstrate knowledge of the toxicological tests and their interpretations.
The teaching methods used will be the carrying out of lectures with in-depth analysis of the program. Therefore, the frequency of lessons is recommended.
An introduction to the general principles of toxicology. Definition and aims of toxicology; toxicological responses: allergic reaction, idiosyncrasy, tolerance; local / systemic effects; acute / chronic effects.
Exposure route, frequency and duration of the exposure; dose-response relationships; threshold dose; hormesis; IT, log-probit transform and curve comparison; power and effectiveness
Toxicological risk and prevention: management of the toxicological data. Toxicological risk assessment for xenobiotics: hazard identification and risk characterization. Toxicity test: acute, subchronic and chronic tests.
Quantitative parameters (DL50, NOAEL, LOAEL, ADI, DNEL). Classification of chemicals. Toxicological test. Factors that influence the response to toxicological agents: individual variability, gender, age, intra-specie and inter-specie variability.
Toxicokinetics: absorption, biotransformation (phase I and II reactions: enzymes, cofactors), distribution and elimination of xenobiotics. Quantitative parameters: Vd, half-life, clearence. Induction and inhibition of CYP450.
Toxicodynamics: release from the exposure site and interaction with functional targets. Main molecular and cellular mechanisms of toxicity. Repair systems.
Carcinogenesis and chemical carcinogens: genotoxic and epigenetic substances
Developmental toxicology: teratogenic substances, mechanisms and kinetics; endocrine disruptors. Organ toxicity.
Special toxicology: contaminants in food, pesticides and environmental pollutants. Food contaminants of natural origin: phytotoxins, mycotoxins, bacterial toxins. Alcoholic beverages. Voluntary and food additives including dyes, flavors.
The food chain as a vehicle and concentration system for toxic substances.
Casarett & Doull Elementi di Tossicologia (a cura di Patrizia Hrelia, Giorgio Cantelli Forti). Casa Editrice Ambrosiana. 2013
Casarett and Doull’s Tossicologia: I fondamenti dell’azione delle sostanze tossiche - Ed. EMSI, 2010
Capuano A. – Dugo G. – Restani P.: Tossicologia degli Alimenti", Torino, UTET, 1998
Ricevimento: By appointment
CHIARA CERVETTO (President)
GUIDO MAURA
MARCO MILANESE
ANNA MARIA PITTALUGA
MANUELA MARCOLI (President Substitute)
see https://corsi.unige.it/11158
To assess student’s achievement of learning, the examination will be an oral exam (30 minutes), always in presence of the Commission consisting of at least of two professors (or sometimes in presence of a professor and an expert subject designated by the CCS).
The Commission will verify the achievement of educational objectives with high accuracy collecting information about the nature and extent of learning outcomes, capacity as well as connection and reasoning within topics of the Course. When the educational objectives will be not achieved, the Student will be invited to verify better the knowledge and possibly to use supplemental explanations contacting the professor.
