The course deals with the pre-treatment and the quantitative determination of substances of pharmaceutical interest. It is developed with theoretical and practical lessons. The topics of the course are listed as follows.
The course consists of lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the pre-treatment and the quantitative determination of compounds with medicinal use.
The course allows to acquire theoretical and practical information regarding the main methods of quantitative analysis of drugs such as volumetric analysis, in particular in the areas of acid-base, complexometric, redox and precipitation titrations. Sample pretreatment and drug determination methods include instrumental analysis such as gas chromatography and HPLC. The laboratory activities concern the dosage of drugs and purification techniques of the sample.
The course is developed with theoretical and practical lessons. The frontal teaching could be also carried out remotely in telematic mode due to the health emergency by COVID19.
Theoretical topics
Guidelines on laboratory safety and chemical use
Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed.
Classification and selection of analitycal methods. Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration.
Techniques of preparing sample: filtration, extraction, distillation, chromatography
Sample characterization
Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions.
Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, Diazotization Titration.
Gascromatoraphy and HPLC.
Practical trainings
Extraction with solvent, distillation in vacuo. TLC.
Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations.
Ricevimento: From Monday to Friday, by email appointment
ELENA CICHERO (President)
PAOLA FOSSA
ANNA CARBONE (Substitute)
FRANCESCA MUSUMECI (Substitute)
MICHELE TONELLI (Substitute)
In the second semester
Oral test. Exams could be carried out remotely in telematic mode due to the health emergency by COVID19.
The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory.
