OVERVIEW

The course deals with the pre-treatment and the quantitative determination of substances of pharmaceutical interest. It is developed with theoretical and practical lessons. The topics of the course are listed as follows.

AIMS AND CONTENT

LEARNING OUTCOMES

The course consists of  lectures and individual trainings in laboratory, aims to provide a basic understanding about the methods for the pre-treatment and the quantitative determination of compounds with medicinal use.

AIMS AND LEARNING OUTCOMES

The course allows to acquire theoretical and practical information regarding the main methods of quantitative analysis of drugs such as volumetric analysis, in particular in the areas of acid-base, complexometric, redox and precipitation titrations. Sample pretreatment and drug determination methods include instrumental analysis such as gas chromatography and HPLC. The laboratory activities concern the dosage of drugs and purification techniques of the sample.

TEACHING METHODS

The course is developed with theoretical and practical lessons. The frontal teaching could be also carried out remotely in telematic mode due to the health emergency by COVID19.

SYLLABUS/CONTENT

Theoretical topics

Guidelines on laboratory safety and chemical use

Introduction to the quantitative determination of compounds registered in FU XII Ed. and FE VIII Ed.

Classification and selection of analitycal methods.  Chemical, apparatus and methods for the quantitative determination of compounds with medicinal uses. Calculation used in pharmaceutical analysis. Sampling, standardization and calibration.

Techniques of preparing sample: filtration, extraction, distillation, chromatography

Sample characterization

Introduction to volumetric titrations in pharmaceutical analysis: chemical equilibria in volumetric analysis. Preparation of standard solutions.

Quantitative determination and applications: neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations, Diazotization Titration.

Gascromatoraphy and HPLC. 

Practical trainings

Extraction with solvent, distillation in vacuo. TLC.

Chromatographyc separation and analysis of a mixture of drugs. Quantitative determination of drugs by mean of neutralization titrations, complexation and precipitation reactions and titrations, oxidation/reduction titrations.

RECOMMENDED READING/BIBLIOGRAPHY

• Principi di Analisi Farmaceutica, Quarta Edizione - V. Cavrini e V. Andrisano, ESCULAPIO
• Analisi Farmaceutica David G. Watson Edra 2014
• Fondamenti di chimica analitica di Skoog e West, Terza Edizione - F. James Holler e Stanley R. Crouch, EDISES – ISBN 9788879598651
• Analisi chimico farmaceutica - F. Savelli e O. Bruno - PICCIN

TEACHERS AND EXAM BOARD

Exam Board

ELENA CICHERO (President)

PAOLA FOSSA

ANNA CARBONE (Substitute)

FRANCESCA MUSUMECI (Substitute)

MICHELE TONELLI (Substitute)

LESSONS

LESSONS START

In the second semester

Class schedule

The timetable for this course is available here: Portale EasyAcademy

EXAMS

EXAM DESCRIPTION

Oral test. Exams could be  carried out remotely in telematic mode due to the health emergency by COVID19.

ASSESSMENT METHODS

The examination includes an oral test and an evaluation of the experimental ability achieved by the student while attending to practical trainings in laboratory.

Exam schedule