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BIOCHEMICAL PROPAEDEUTICS

CODE 75095
ACADEMIC YEAR 2021/2022
CREDITS
  • 6 cfu during the 1st year of 9293 TECNICHE DI LABORATORIO BIOMEDICO(L/SNT3) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/10
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 2° Semester
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    OVERVIEW

    The course consist of two modules: Propedeutical Biochemistry and Biochemistry, and is divided into two parts: a part of lessons in presence and one part, as support of the first, consisting of online classes.

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The first part of the course aims to provide the basis of general and organic chemistry to address Biochemistry,  the second part of the course. The aim of this second part is both the acquisition of knowledge about the structure and function of proteins and enzymes proteins as the main pathways of carbohydrate, fat, and protein catabolism.

    AIMS AND LEARNING OUTCOMES

    The first part of the course aims to provide the basis of general and organic chemistry to address Biochemistry,  the second part of the course. The aim of this second part is both the acquisition of knowledge about the structure and function of proteins and enzymes proteins as the main pathways of carbohydrate, fat, and protein catabolism.

    TEACHING METHODS

    The lessons will be carried out if possible in presence, guaranteeing however the fruition of the lessons even remotely, through video recording, synchronous or asynchronous. All face-to-face activities will be carried out in compliance with the classroom capacity limits and the distance provided for by current legislation following the COVID19 emergency.

    Please refer to the specific AulaWeb application for any updates due to changes in the health and epidemiological situation.

    SYLLABUS/CONTENT

    PROPEDEUTICAL BIOCHEMISTRY solutions. Properties and  units of measure: molarity, normality,% w / w% w / v. osmotic pressure. The chemical reactions. chemical balance. chemical kinetics. Reaction speed. Catalysis and enzymatic catalysis, Km. Thermodynamics. Concepts of enthalpy and entropy. Spontaneity of reactions, free energy. Ionization of water. pH. Acidity and alkalinity. Strong and weak acids and bases,  hydrolysis, buffers. The chemistry of carbon, the carbon valence. The functional groups. Alcohols and thiols. Redox reactions. Oxidation of alcohols and thiols. Aldehydes and ketones. Hemiacetals. Amines. Carboxylic acid. Amides, esters and anhydrides. Fatty acids. Triglycerides. Phospholipids. Biomolecules and their functional groups. Carbohydrates: Monosaccharides: glucose, fructose, ribose and deoxyribose, disaccharides: sucrose, and polysaccharides, cellulose, glycogen. Amino acids. Peptides and proteins. The peptide bond. protein structure.

    Biochemistry Myoglobin.  Hemoglobin. Enzymes: structure and function. Catabolism and anabolism: general concepts of the intermediate metabolism. Glycolysis, gluconeogenesis and glucose:  regulation. Lactate cycle. Krebs cycle. Strategies for ATP synthesis. Synthesis and degradation of glycogen. Oxidation of fatty acids. Chetonic bodies. Amino acids catabolism: urea cycle.

    RECOMMENDED READING/BIBLIOGRAPHY

    Catani, Savini, Guerrieri, Avigliano “Appunti di Biochimica per le lauree triennali” Editore: Piccin
    Stefani, Taddei “Chimica biochimica e biologia applicata” Editore: Zanichelli

    TEACHERS AND EXAM BOARD

    Exam Board

    MONICA AVERNA (President)

    PIETRO BALDELLI (President)

    PIERLUIGI VALENTE

    MARIO PASSALACQUA (President and Coordinator of Integrated Course)

    LESSONS

    LESSONS START

    Consult detailed timetable at the following link: https://easyacademy.unige.it/portalestudenti/

    Class schedule

    All class schedules are posted on the EasyAcademy portal.

    EXAMS

    EXAM DESCRIPTION

    Oral examination

    Please refer to the specific AulaWeb application for any updates due to changes in the health and epidemiological situation.

    ASSESSMENT METHODS

    Oral examination with assessment of knowledge and ability to link between the various topics in the program. To establish the degree of competence acquired by the students, with respect to the program of this teaching, the commission will positively evaluate the ability to analyze and integrate different aspects of the proposed question and the use of an appropriate vocabulary.