Salta al contenuto principale della pagina

CLINICAL PATHOLOGY

CODE 104201
ACADEMIC YEAR 2021/2022
CREDITS
  • 12 cfu during the 2nd year of 11158 BIOLOGIA APPLICATA E SPERIMENTALE(LM-6) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR MED/05
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER Annual
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The module provides the fundamental knowledge to evaluate the results of the main laboratory diagnostic analyses. In addition to the general methodological skills and to the knowledge of the most important instruments, the module provides the general clinical pathology expertises (accuracy and precision, diagnostic sensitivity and specificity, methodological sensitivity and specificity, positive and negative predictive value, normal range , decision-making levels) and investigates their clinical significance related to the various pathological conditions (e.g. inflammatory pathologies, cell damage and tumors, ect.). This module and the Clinical Biochemistry module will provide students with the fundamental skills of Laboratory Medicine.

    AIMS AND LEARNING OUTCOMES

    The teaching of Clinical Pathology will integrate with the teaching of Clinical Biochemistry to provide students with medium-advanced knowledge on all fields of laboratory medicine, to prepare students for a possible career in this direction, subject to the achievement of the Specialization Dilpoma in Clinical Pathology and Clinical Biochemistry.

    The student will have to demonstrate to be able to know all the main diagnostic tests and their applications, their meaning and their limitations, and also to choose which tests are indicated in the various human pathologies. The student at the highest level of preparation will have to reach the ability to decide which exams and in what order should be performed according to the pathology considered.

    TEACHING METHODS

    The teaching will be essentially delivered through lectures, during which however the teacher will try to interactively involve the students.

    NON-certification formative tests are possible during the course. They will NOT be taken into account for the outcome of the final exam.

    In case of persistence of the COVID-19 emergency, the lessons can be delivered online, preferably through the TEAMS platform.

    SYLLABUS/CONTENT

    Nicola Traverso (2 CFU)

    General principles of clinical pathology (part 1)

    Concepts of accuracy, precision, specificity and diagnostic sensitivity, methodological specificity and sensitivity, positive and negative predictive values; quality control

    Cell damage markers

    Main enzymes and serum proteins of diagnostic interest

    Liver function test

    Enzymes of diagnostic interest for hepatocellular pathologies and biliary stasis

    Bilirubin metabolism and jaundice

    Diagnostic markers in viral hepatitis

    Diagnostic markers in chronic alcoholism

     

    Test for lipid metabolism

    Lipoprotein and apolipoprotein classification

    Reference and atherosclerotic risk values

    Dyslipidemic phenotypes

    Cardiovascular and homocysteine ​​risk

     

    Renal function and balance of body fluids

    Kidney function test: indicators of glomerular and tubular malfunction

    Hydro-electrolyte balance: sodium, water, potassium, calcium, phosphorus

    Acid base balance (blood gas analysis)

    Etiology of the disorders and changes in values ​​in the conditions of metabolic and respiratory acidosis and alkalosis. Compensation mechanisms and forecast tables of expected EGA values

     

    Anna Lisa Furfaro (2 CFU)

    LABORATORY DIAGNOSTICS OF INFLAMMATION

    Electrophoretic profile of proteins, and acute phase proteins

    PCR and ESR

    Sepsis markers

     

    Cardiac diagnostics

    Laboratory diagnosis of myocardial infarction

    Laboratory diagnosis of heart failure

     

    Laboratory ONCOLOGICAL DIAGNOSTICS

    Serum tumor markers

    Liquid biopsy

    Faecal Occult Blood Assay (FOBT)

     

    THE LABORATORY IN THE DIAGNOSTICS OF THE NUTRITIONAL STATE

    Nutritional status indicators

    Serum vitamins and their diagnostic significance

     

     

    Anna Maria Bassi (1CFU)

     

    General principles of clinical disease (part 2)

    Meaning of the laboratory test request. Exams performed in routine or in an emergency regime

    Biological and physical causes of variations in results

     

    URINALYSIS

    Extemporaneous sample examination and timed collection examination.

    Physico-chemical examination of urine

    Urinary sediment examination

    Measurement of physiological and pathological chemical components (ions, salts, proteins, glucose, ketone bodies, amino acids, enzymes, bilirubin)

     

    LABORATORY DIAGNOSTICS FOR THE GASTROINTESTINAL SYSTEM

    Diagnosis of Helicobacter pylori infection

    Serum markers of pancreatitis

     

     

    Giampaola Pesce (1 CFU)

    THE LABORATORY IN AUTOIMMUNE AND TRANSPLANT PATHOLOGIES

    Laboratory diagnostics in autoimmune diseases.

     

    Additional seminar:

    Histocompatibility test (Invited lecturer, prof Alessandro Poggi, 2 hours)

    RECOMMENDED READING/BIBLIOGRAPHY

    All the material that the teachers will use during the lessons will be made available to the students of the course for study purposes through aulaweb.

    A useful and comprehensive treatise on laboratory medicine is

    Henry's, Clinical diagnosis and managements by Laboratory methods, Elsevier

    TEACHERS AND EXAM BOARD

    Exam Board

    ELENA ZOCCHI (President)

    ANNA MARIA BASSI

    ANNA LISA FURFARO

    GIAMPAOLA PESCE

    NICOLA TRAVERSO (President Substitute)

    LESSONS

    LESSONS START

    Second semester of the academic year of reference (indicatively beginning of March)

    Class schedule

    CLINICAL PATHOLOGY

    EXAMS

    Exam schedule

    Date Time Location Type Notes
    27/06/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.
    18/07/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.
    01/09/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.