AIMS AND CONTENT

LEARNING OUTCOMES

AIMS AND LEARNING OUTCOMES

The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of the laboratory test that explore the function of specific organs/apparatuses. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests. Students will realize the extent and severity of deviation from the normal range of the laboratory test discussed in the course during pathological conditions. Students will be able to identify the most appropriate laboratory tests to address specific diagnostic hypotheses and evaluate the results in terms of confirming or disproving these hypotheses. 

TEACHING METHODS

Face-to-face or video-recorded lessons (in presence), available on aulaweb

Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.

SYLLABUS/CONTENT

1-BLOOD

The complete blood count

Electrophoretic profile of serum proteins and its diagnostic interpretation

Principal serum enzymes of diagnostic interest

Non-protein nitrogen

Iron metabolism, quantitative and qualitative defects of hemoglobin

Electrolytes

Morphological and pathognetic classification of anemias

2-LIVER FUNCTION TESTS

Enzymes, bilirubin and jaundice, modifications of serum proteins in selected liver diseases, coagulation factors, diagnosis of selected liver diseases

3-GLUCOSE METABOLISM

Hormones regulating glycemia

Causes of hyper- and hypo-glycemia

Lab tests in diabetes mellitus

Lab tests in chetoacidosis, glucose tolerance test, gestational diabetes.

4-LIPID METABOLISM

Lipoprotein classification and function

Reference values for blood lipids

Hyperlipidemic profiles and cardiovascular risk

5-URINE ANALYSIS AND TESTS OF RENAL FUNCTION

The physical-chemical urineanalysis

Renal functional tests: indicators of glomerular and tubular malfunction

6-TESTS FOR ENDOCRINE DISORDERS

Steroid, peptide and aminoacid-derived hormones: basal levels and pathologic conditions of hyper/hypo-secretion

Lab tests in the diagnosis of endocrinological disorders

7- HEART

Markers of myocardial necrosis and ischemia

Markers of heart failure

8-TESTS OF PANCREATIC FUNCTION

9-ARTERIAL BLOOD GASES AND ACID-BASE BALANCE

10-INFLAMMATION

Common markers of inflammation

Specific markers of inflammation for selected (auto)inflammatory and autoimmune diseases

RECOMMENDED READING/BIBLIOGRAPHY

on-line available (aula web) slides

Common laboratory tests - Vaughn G. Appleton & Lange

TEACHERS AND EXAM BOARD

Exam Board

ELENA ZOCCHI (President)

ANNA MARIA BASSI

ANNA LISA FURFARO

GIAMPAOLA PESCE

NICOLA TRAVERSO (President Substitute)

LESSONS

Class schedule

CLINICAL BIOCHEMISTRY

EXAMS

EXAM DESCRIPTION

The examination will consist of a written test (multiple-choice quiz) performed live in the classroom or on a digital platform, in line with the University's regulations regarding anti-covid safety standards.

Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.

ASSESSMENT METHODS

The exam will verify the achievement of the learning outcomes; in particular, it will ascertain the student's knowledge of the clinical meaning of the biochemical-clinical parameters presented during the lessons, of the unit of measure in which they are expressed and of their dynamic range in the main pathologies for which they represent a diagnostic-prognostic tool. The ability to choose, among some proposed tests, those suitable to solve a specific diagnostic question, and the ability to identify deviations from the norm indicative of pathology, will be evaluated.