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CLINICAL BIOCHEMISTRY

CODE 104202
ACADEMIC YEAR 2021/2022
CREDITS
  • 12 cfu during the 2nd year of 11158 BIOLOGIA APPLICATA E SPERIMENTALE(LM-6) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/12
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER Annual
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    LEARNING OUTCOMES

    AIMS AND LEARNING OUTCOMES

    The aim of the clinical biochemistry part of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests of the “clinical chemistry profile” and of the laboratory test that explore the function of specific organs/apparatuses. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests. Students will realize the extent and severity of deviation from the normal range of the laboratory test discussed in the course during pathological conditions. Students will be able to identify the most appropriate laboratory tests to address specific diagnostic hypotheses and evaluate the results in terms of confirming or disproving these hypotheses. 

    TEACHING METHODS

    Face-to-face or video-recorded lessons (in presence), available on aulaweb

    Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.

    SYLLABUS/CONTENT

    1-BLOOD

    The complete blood count

    Electrophoretic profile of serum proteins and its diagnostic interpretation

    Principal serum enzymes of diagnostic interest

    Non-protein nitrogen

    Iron metabolism, quantitative and qualitative defects of hemoglobin

    Electrolytes

    Morphological and pathognetic classification of anemias

    2-LIVER FUNCTION TESTS

    Enzymes, bilirubin and jaundice, modifications of serum proteins in selected liver diseases, coagulation factors, diagnosis of selected liver diseases

    3-GLUCOSE METABOLISM

    Hormones regulating glycemia

    Causes of hyper- and hypo-glycemia

    Lab tests in diabetes mellitus

    Lab tests in chetoacidosis, glucose tolerance test, gestational diabetes.

    4-LIPID METABOLISM

    Lipoprotein classification and function

    Reference values for blood lipids

    Hyperlipidemic profiles and cardiovascular risk

    5-URINE ANALYSIS AND TESTS OF RENAL FUNCTION

    The physical-chemical urineanalysis

    Renal functional tests: indicators of glomerular and tubular malfunction

    6-TESTS FOR ENDOCRINE DISORDERS

    Steroid, peptide and aminoacid-derived hormones: basal levels and pathologic conditions of hyper/hypo-secretion

    Lab tests in the diagnosis of endocrinological disorders

    7- HEART

    Markers of myocardial necrosis and ischemia

    Markers of heart failure

    8-TESTS OF PANCREATIC FUNCTION

    9-ARTERIAL BLOOD GASES AND ACID-BASE BALANCE

    10-INFLAMMATION

    Common markers of inflammation

    Specific markers of inflammation for selected (auto)inflammatory and autoimmune diseases

     

    RECOMMENDED READING/BIBLIOGRAPHY

    on-line available (aula web) slides

    Common laboratory tests - Vaughn G. Appleton & Lange

    TEACHERS AND EXAM BOARD

    Exam Board

    ELENA ZOCCHI (President)

    ANNA MARIA BASSI

    ANNA LISA FURFARO

    GIAMPAOLA PESCE

    NICOLA TRAVERSO (President Substitute)

    LESSONS

    EXAMS

    EXAM DESCRIPTION

    The examination will consist of a written test (multiple-choice quiz) performed live in the classroom or on a digital platform, in line with the University's regulations regarding anti-covid safety standards.

    Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.

    ASSESSMENT METHODS

    The exam will verify the achievement of the learning outcomes; in particular, it will ascertain the student's knowledge of the clinical meaning of the biochemical-clinical parameters presented during the lessons, of the unit of measure in which they are expressed and of their dynamic range in the main pathologies for which they represent a diagnostic-prognostic tool. The ability to choose, among some proposed tests, those suitable to solve a specific diagnostic question, and the ability to identify deviations from the norm indicative of pathology, will be evaluated.

    Exam schedule

    Date Time Location Type Notes
    27/06/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.
    18/07/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.
    01/09/2022 10:00 GENOVA Scritto + Orale Appello del 27 giugno: gli studenti che vogliano, possono sostenere il colloquio di Patologia clinica il giorno stesso (27 giugno). Sede: Aula di Patologia generale. Accesso da Viale Benedetto XV Appello del 18 luglio Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra. Appello del 1° settembre Sede (da confermare): Auletta di patologia generale. Accesso da Via Leon Battista Alberti 2, piano terra.