OVERVIEW

Molecular Bases of Diseases is a fundamental teaching for the "Food and Nutrition" curriculum and for the "Biomedical" curriculum.

AIMS AND CONTENT

LEARNING OUTCOMES

The course provides in-depth knowledge of the molecular mechanisms that underlie the most important human diseases. The changes in the structure, functions and control mechanisms underlying degenerative or progressive changes will be studied at the molecular, cellular and tissue level, with particular reference to the etiology and pathogenesis of neoplastic transformation and the main metabolic diseases. The knowledge acquired is fundamental in the preparation of professionals in the food / nutrition sector, as well as in research and in the clinical laboratory.

AIMS AND LEARNING OUTCOMES

The in-depth study of the molecular mechanisms responsible for the alteration of tissue homeostasis and the pathogenesis of the main human diseases allows the acquisition of a solid cultural basis and the critical tools necessary for the student both in the applicative field of research (basic or applied) and in the approach to laboratory diagnostics. Specifically, the student will be able to

-discriminate between the cell and tissue alterations found in the main human pathologies and identify typical molecular alterations.

- to relate molecular or cellular alterations in common to different pathologies,

- classify the different nosological entities,

- acquire specific and specialized terminology.

PREREQUISITES

To properly deal with the contents of the course, solid knowledge is required in relation to biochemistry (signal transduction, protein synthesis, mitochondrial functions, cell cycle), anatomy (the heart and blood circulation, the lymphatic system, the liver, the pancreas), human physiology  (the regulation of glycemia, blood, hemostasis) and general immunology.

TEACHING METHODS

48 hours of lectures with multimedia presentations

SYLLABUS/CONTENT

Adaptations: modifications of cell growth and differentiation. Atrophies, hypertrophies, metaplasia.

Neoplasia: Atypia of the neoplastic cell. Metastasis. Benign tumors and malignant tumors. Histopathological classification. TNM system. Molecular mechanisms of carcinogenesis. Oncogenes and tumor suppressors. Carcinogenic chemicals, radiation, viruses. Cancer progression.

Cellular and tissue degeneration: Primary dysfunctions, intracellular accumulations, extracellular accumulations.

Amyloidosis

Liver disorders: Steatosis, Fibrosis, Cirrhosis. Hemosiderosis, Alcohol damage

Atherosclerosis - pathogenesis and sequelae

Diabetes: pathogenesis and sequelae

Deficiency states: Iron deficiency, Vit. C, Vit. D, Vit. B12

Mucosal immunity - characteristics of IS associated with mucous membranes, organization of the immune system of mucous tissues, lymphoid tissues and lymphocyte populations associated with the intestine.

Role of the microbiota in immunity and inflammation.

Microbiota- dietary factors- and food allergies

Diseases related to immune responses in the intestine:

Type I, II, III and IV hypersensitivity reactions

RECOMMENDED READING/BIBLIOGRAPHY

Information will be provided during the lessons

TEACHERS AND EXAM BOARD

Exam Board

MARIAPAOLA NITTI (President)

ANNA LISA FURFARO

GABRIELLA PIETRA (President Substitute)

LESSONS

LESSONS START

First semester

Class schedule

MOLECULAR BASIS OF DISEASES

EXAMS

EXAM DESCRIPTION

Oral examination

ASSESSMENT METHODS

The student must correctly answer 3 questions relating to the exam program. For final evaluation, the commission will evaluate the following requirements: the level of knowledge of the topics covered by the questions, the acquisition of specialized vocabulary and the ability to present and connect different related topics.

Exam schedule