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PATHOPHYSIOLOGY AND IMMUNOPATHOLOGY

CODE 104849
ACADEMIC YEAR 2021/2022
CREDITS
  • 12 cfu during the 2nd year of 11158 BIOLOGIA APPLICATA E SPERIMENTALE(LM-6) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR MED/04
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER 1° Semester
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    LEARNING OUTCOMES

    The course aims at providing students with the in-depht knowledge the main pathophysiological conditions as well as the immunopatholgical disorders. The deep knowledge provided in this course will be fundamental for the full understanding of laboratory medicine and then in the activities in clinical and experimental laboratories.

    AIMS AND LEARNING OUTCOMES

    The full knowledge of the pathophysiological alterations and immune system pathologies allows to understand the fundamentals of laboratory medicine, facilitating the interpretation of clinical data in the framework of the organ/apparatus dysfunctions. This knowledge, complemented by the knowledge of the pathogenetic mechanisms of diseases acquired in the first module of the annual teaching, prepares future professionals in clinical/diagnostic and research laboratories.

    TEACHING METHODS

    48 hours of lectures with multimedia presentations

    SYLLABUS/CONTENT

    Anemias
    Hemostasis and thrombosis
    Hemorrhagic diathesis: congenital and acquired alterations. CID
    Vascular disorders: edema, embolism, heart attack, shock.
    
    Digestive system (gastroesophageal reflux, ulcer, Chron's disease, ulcerative colitis and pancreatitis).
    Pathophysiology of the liver: portal hypertension and hepatic insufficiency
    Pathophysiology of the heart (defects in strength, electrical changes, valve defects, acute and chronic heart failure)
    Pathophysiology of the lung (ventilation defects, obstructive and restrictive syndromes, gas exchange defects, significance of hypercapnia)
    Pathophysiology of the kidney (glomerular, tubular, interstitial, vascular and urinary tract diseases; acute and chronic insufficiency)
    Endocrine and genital (hypo- and hormonal hypersecretions; fertility)
    
    Immunological memory Vaccines - Principle of vaccination. Active and passive immunization. Main types of vaccines. Adjuvants.
    Congenital immunodeficiencies of innate and acquired immunity
    Secondary immune deficiencies (HIV)
    Autoimmunity - Mechanisms of central and peripheral tolerance. Classification of the main autoimmune diseases and their characteristics
    Anti-tumor immunity - Effector cells and evasion mechanisms of tumor immunosurveillance. Cancer Immunoediting. Tumor immunotherapy. Microbiome, tumors and response to anti-tumor therapies
    Transplants - Solid organ transplants, classification and mechanisms of rejection. Allor direct and indirect recognition. Immunosuppressive drugs. Hematopoietic stem cell transplantation

    RECOMMENDED READING/BIBLIOGRAPHY

    Information will be provided during the lessons

    TEACHERS AND EXAM BOARD

    Exam Board

    MARIAPAOLA NITTI (President)

    ANNA LISA FURFARO

    NICOLA TRAVERSO

    GABRIELLA PIETRA (President Substitute)

    LESSONS

    LESSONS START

    See lesson calendar

    EXAMS

    EXAM DESCRIPTION

    Oral examination on topics covered during lessons.

    ASSESSMENT METHODS

    The student must correctly answer 3-4 questions. For final evaluation, the commission will evaluate the following requirements: the level of knowledge of the topics covered by the questions, the acquisition of specialized vocabulary and the ability to present and connect different related topics.

    Exam schedule

    Date Time Location Type Notes
    17/01/2022 09:00 GENOVA Orale
    31/01/2022 09:00 GENOVA Orale
    16/02/2022 09:00 GENOVA Orale
    08/06/2022 09:00 GENOVA Orale
    22/06/2022 09:00 GENOVA Orale
    08/07/2022 09:00 GENOVA Orale
    25/07/2022 09:00 GENOVA Orale
    15/09/2022 09:00 GENOVA Orale