|SCIENTIFIC DISCIPLINARY SECTOR||MED/05|
|MODULES||This unit is a module of:|
The Clinical Pathology III course deals with biological assays and laboratory blood tests characteristic of organ and bone marrow transplantation and autoimmune diseases.
Aim of the course is to provide the principles underlie to a) organ and hematopoietic stem cell transplantation, b) main features of autoimmune diseases. This aim focusing on in vitro assays to evaluate donor-recipient compatibility and biological parameters indicating: graft rejection and GVHD, diagnosis and progression of autoimmune disease.
The main aim of the course is to describe and analyze in detail a) the molecular mechanisms underlying the graft versus host compatibility in the organ or the hematopoietic stem cells graft; b) the laboratory methods applied to determine this compatibility and the biochemical/molecular features of incompatibility reactions after the organ or hematopoietic stem cells graft (i.e. graft versus host disease and graft reaction); c) pathogenetic mechanisms of systemic and organ-specific autoimmune diseases; d) humoral and cellular parameters altered in autoimmune diseases.
The student has a) to know the reason why there is the graft versus host incompatibility, graft versus host reaction or graft rejection; b) to identify the methods applied to evaluate biological parameters during the above-mentioned reactions; c) to know the serum parameters and the methods to evaluate these parameters during systemic and organ-specific autoimmune diseases; d) to identify on the basis of a specific parameter the autoimmune disease and in which phase, among those analyzed in the program, may be present.
It is important that the student knows the basic principles of immune responses, the phenotype and function of T and B lymphocytes as well as antigen-presenting cells. Indeed, Innate and adaptive immune reactions are involved in autoimmune disorders and in all the reactions that may follow to organ transplantation or hematopoietic stem cells infusion.
Classroom-taught lectures, queries and replies on the next lesson, problem-based learning. This can be achieved also by the Teams informatics platform where the students can find recorded lessons in the section of the "materiale del corso" in the course specific team..
Organ and bone marrow transplantation, markers of transplant rejection, graft versus host disease (GVHD), methods to assess donor-recipient compatibility, methods to assess biological parameters during graft rejection and GVHD, basic principle of auto-reactivity, autoimmunity and autoimmune diseases, organ specific autoimmune diseases, autoimmune hepatitis, celiac disease, systemic autoimmune diseases, systemic lupus erythematosus, methods to assess biological parameters and diagnose autoimmune diseases.
Office hours: Students can book an appointment with the professor usually by the professor's email (email@example.com) and students will agree on date and time. Also, the students can get in touch the professor through the Teams platform using the specific team.
paolo CARLIER (President)
ANNA LISA FURFARO (President)
ALESSANDRO POGGI (President)
NICOLA TRAVERSO (President and Coordinator of Integrated Course)
All class schedules are posted on the EasyAcademy portal.
The student will be examined answering three queries on procedures and biological parameters relevant in pathological/clinical conditions that are subject of the course. The examination will be passed if the student knows and is able to assess which and how biological parameters should be studied in those pathological/clinical conditions.