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CLINICAL BIOCHEMISTRY

CODE 104202
ACADEMIC YEAR 2022/2023
CREDITS
  • 12 cfu during the 2nd year of 11158 BIOLOGIA APPLICATA E SPERIMENTALE(LM-6) - GENOVA
  • SCIENTIFIC DISCIPLINARY SECTOR BIO/12
    LANGUAGE Italian
    TEACHING LOCATION
  • GENOVA
  • SEMESTER Annual
    MODULES This unit is a module of:
    TEACHING MATERIALS AULAWEB

    AIMS AND CONTENT

    LEARNING OUTCOMES

    AIMS AND LEARNING OUTCOMES

    The aim of the clinical biochemistry module of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests that explore the function of specific organs/apparatuses. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests. Students will realize the extent and severity of deviation from the normal range of the laboratory test discussed in the module during pathological conditions. Students will be able to identify the most appropriate laboratory tests to address specific diagnostic hypotheses and evaluate the results in terms of confirming or disproving these hypotheses. 

    TEACHING METHODS

    Face-to-face or video-recorded lessons (in presence), available on aulaweb, depending on University anti-covid guidelines

    Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.

    The lecturer will present the various laboratory tests and simple case studies will be used to exemplify the clinical use of the tests for diagnosis, prognosis or disease exclusion.

    SYLLABUS/CONTENT

    Hematologic diagnostics

    The CBC

    Iron metabolism

    Anemias (morfological and eziological classification)

    Hemoglobinopathies  (thalassemia syndromes and structural hemoglobin variants)

    Hemostasis

    Markers of hemorragic/thrombotic risk

     

    Diabetes Mellitus Diagnosis

    Hormones regulating glycemia

    Causes of hyper- and hypo-glycemia

    Diagnostic criteria for DM and GDM

    Lab tests in diabetic ketoacidosis; OGTT; HbA1c; ketone bodies

    Clinical cases of metabolic acidosis

     

    The endocrinological lab

    Steroid, peptide and aminoacid-derived hormones: functions, basal levels and conditions of increased and reduced secretion

    Lab tests exploring hormonal production:  the hypothalamus/pituitary axis; thyroid function, surrenal and sex hormones

     

    The lab in pediatric diseases

    The neonatal extended screening

    Differential diagnosis in childhood obesity

     

    The lab in digestive diseases

    Inflammatory bowel diseases, celiac disease, breath tests, acute and chronic pancreatitis, FOB

     

    The lab in CNS diseases  

    The CSF, production, functions, CSF test (normal and abnormal results of the cytometric and biochemical tests), markers of AD and C-J diseases, CSF leakage.

     

    The lab in respiratory diseases.

    Pneumonia, COPD, pulmonary embolism.

     

    RECOMMENDED READING/BIBLIOGRAPHY

    on-line available (aula web) slides

    Common laboratory tests - Vaughn G. Appleton & Lange

    Medicina di laboratorio, M. Ciaccio et al., Edises

    TEACHERS AND EXAM BOARD

    LESSONS

    LESSONS START

    For lessons start and timetable go to the link: https://easyacademy.unige.it/portalestudenti/

    Please check the module Aulaweb page for timetable updates dependent on the sanitary and epidemic situation.

    EXAMS

    EXAM DESCRIPTION

    The exam will consist of a written test (multiple-choice quiz, 30+1 questions) taken on site or on a digital platform, consistent with University regulations regarding anti-covid safety standards.

    The test is passed with at least 18/30.

    The final grade will be averaged (weighted average) with that of Clinical Pathology.

    ASSESSMENT METHODS

    The exam will verify the achievement of the learning outcomes; in particular, it will ascertain the student's knowledge of the clinical meaning of the biochemical-clinical parameters presented during the lessons, of the unit of measure in which they are expressed and of their dynamic range in the main pathologies for which they represent a diagnostic-prognostic tool. The ability to choose, among some proposed tests, those suitable to solve a specific diagnostic question, and the ability to identify deviations from the norm indicative of pathology, will be evaluated.