| CODE | 108671 |
|---|---|
| ACADEMIC YEAR | 2022/2023 |
| CREDITS |
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| SCIENTIFIC DISCIPLINARY SECTOR | CHIM/09 |
| LANGUAGE | Italian |
| TEACHING LOCATION |
|
| SEMESTER | 2° Semester |
| MODULES | This unit is a module of: |
| TEACHING MATERIALS | AULAWEB |
Latentiation and Retrometabolic Drugs Design is the discipline dealing with all the technological and scientific aspects indispensable in order to develop new prodrugs (also known as drugs latentiation) and new soft drugs and release chemical systems (both of them belong to Retrametabolic Drugs Design). Therefore in this course all the strategies carried out to optimize the therapeutic index of a new active ingredient, are exhaustively treated.
Providing students all the fundamental principles they need to know how to develop new drugs endowed with improved targeting, release and high therapeutic index.
Providing students all the fundamental principles about latentiation and retrometabolic drug design. At the end of the course, students will be able to:
• describe the main strategies to obtain chemical latent forms of new drugs
• describe the main strategies to design soft drugs and release chemical systems
• know the differences among prodrugs, soft drugs and release chemical systems.
To completely understand all the topics treated in the course, students need to have already passed the following exams: organic chemistry; toxicological and medicinal chemistry I.
In case of particular situations, theoretical lessons may be held also online and they are aimed at simplifying the comprehension of the pharmaceutical topics treated. In this context the teacher supports particular closer examination of those topics particularly difficult to understand for students. Before starting a new lesson, to facilitate students to learn several connected chapters, a brief summing up of the previous lesson is carried out.
Definition of prodrug and analogue
Classification of prodrugs
Fortuitous and intentional prodrugs
Main problems leading to the design of prodrugs (with examples)
Definition of soft drug
Main categories of soft drugs (with examples)
Definition of release chemical system
Main categories of release chemical systems (with examples).
A specific, designated book for this subject doesn't exist. The content of the course consists of topics put together properly by the teacher and deriving from updated and reliable reviews in the field of drugs latentiation and retrometabolic drug design. Each chapter is exaustively explained to students throughout the lessons and, for every chapter, comprehensive notes are available on Aulaweb.
Office hours: Depending on his own professional engagements and by appointment, the teacher is always available to receive students.
BRUNO TASSO (President)
ELEONORA RUSSO
Classes usually start in the first academic half year with a weekly engagement of 1 lesson lasting 2 hours and set according to the professional errands of both students and teacher.
All class schedules are posted on the EasyAcademy portal.
In case of particular situations the exam may also be taken online, it is an oral exam and it lasts about 20 - 30 minutes for each students. Questions deal with 3 topics chosen by the teacher among the subjects treated during the course.
Teacher assesses student's ability to both explain clearly all the topics treated in the course and write correctly chemical structures involved in the exam questions.
Throughout the course but also before exams, depending on student's request, the teacher is available to offer additional explanations about subjects discussed during the course and considered more difficult to learn by students.