|SCIENTIFIC DISCIPLINARY SECTOR
|Questo insegnamento è un modulo di:
AIMS AND CONTENT
AIMS AND LEARNING OUTCOMES
The aim of the clinical biochemistry module of the course is to allow the student to acquire basic knowledge on the clinical-diagnostic significance of the laboratory tests that explore the function of specific organs/apparatuses. This knowledge will be applied to the discussion of simple case-studies, allowing the students to put into practice the basic knowledge acquired and test their understanding of laboratory tests. Students will realize the extent and severity of deviation from the normal range of the laboratory test discussed in the module during pathological conditions. Students will be able to identify the most appropriate laboratory tests to address specific diagnostic hypotheses and evaluate the results in terms of confirming or disproving these hypotheses.
Face-to-face or video-recorded lessons (in presence), available on aulaweb, depending on University anti-covid guidelines
Please refer to the AulaWeb instance specific to the teaching for any updates due to changes in the health and epidemiological situation.
The lecturer will present the various laboratory tests and simple case studies will be used to exemplify the clinical use of the tests for diagnosis, prognosis or disease exclusion.
Anemias (morfological and eziological classification)
Hemoglobinopathies (thalassemia syndromes and structural hemoglobin variants)
Markers of hemorragic/thrombotic risk
Diabetes Mellitus Diagnosis
Hormones regulating glycemia
Causes of hyper- and hypo-glycemia
Diagnostic criteria for DM and GDM
Lab tests in diabetic ketoacidosis; OGTT; HbA1c; ketone bodies
Clinical cases of metabolic acidosis
The endocrinological lab
Steroid, peptide and aminoacid-derived hormones: functions, basal levels and conditions of increased and reduced secretion
Lab tests exploring hormonal production: the hypothalamus/pituitary axis; thyroid function, surrenal and sex hormones
The lab in pediatric diseases
The neonatal extended screening
Differential diagnosis in childhood obesity
The lab in digestive diseases
Inflammatory bowel diseases, celiac disease, breath tests, acute and chronic pancreatitis, FOB
The lab in CNS diseases
The CSF, production, functions, CSF test (normal and abnormal results of the cytometric and biochemical tests), markers of AD and C-J diseases, CSF leakage.
The lab in respiratory diseases.
Pneumonia, COPD, pulmonary embolism.
on-line available (aula web) slides
Common laboratory tests - Vaughn G. Appleton & Lange
Medicina di laboratorio, M. Ciaccio et al., Edises
TEACHERS AND EXAM BOARD
Ricevimento: By appointment via email (firstname.lastname@example.org) at DIMES, Viale Benedetto XV No. 1, first floor, Genova.
Ricevimento: On appointment , Prof. Maurizio Bruschi, IRCCS Istituto Giannina Gaslini. Laboratorio di Nefrologia Molecolare (Padiglione 12, fondi) Via Gerolamo Gaslini, 5 – 16147 Genova (GE) E-mail: email@example.com
ELENA ZOCCHI (President)
ANNA MARIA BASSI
ANNA LISA FURFARO
NICOLA TRAVERSO (President Substitute)
For lessons start and timetable go to the link: https://easyacademy.unige.it/portalestudenti/
Please check the module Aulaweb page for timetable updates dependent on the sanitary and epidemic situation.
The exam will consist of a written test (multiple-choice quiz, 30+1 questions) taken on site or on a digital platform, consistent with University regulations regarding anti-covid safety standards.
The test is passed with at least 18/30.
The final grade will be averaged (weighted average) with that of Clinical Pathology.
The exam will verify the achievement of the learning outcomes; in particular, it will ascertain the student's knowledge of the clinical meaning of the biochemical-clinical parameters presented during the lessons, of the unit of measure in which they are expressed and of their dynamic range in the main pathologies for which they represent a diagnostic-prognostic tool. The ability to choose, among some proposed tests, those suitable to solve a specific diagnostic question, and the ability to identify deviations from the norm indicative of pathology, will be evaluated.