CODE 57758 ACADEMIC YEAR 2023/2024 CREDITS 2 cfu anno 1 8747 (LM-67) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: PHYSIOPATHOLOGY OF AGING TEACHING MATERIALS AULAWEB OVERVIEW This course is focused on the pathophysiological mechanisms underlying the development of the major disorders that afflict elderly subjects. The course will analyze the role of atherosclerosis in aging: the process of formation of the atheroma is one of the factors involved in the diseases affecting older people. Likewise, cancer pathologies (both benign and malignant) will be investigated. Finally, the role of inflammation in biological aging processes will be assessed. AIMS AND CONTENT LEARNING OUTCOMES To know how the response affects both the biological and the pathological processes in the elderly subjects. AIMS AND LEARNING OUTCOMES -Role of atherosclerosis in Aging. Atheroma is one of the factor involved in several pathologies that affect elderly patients (ACS, ictus, ect). -Tumors are also frequent in aged individuals. Thus, this course focuses on the biology of benign and malignant neoplasias. - Role of Inflammation in Biological Aging Processes. The chronic inflammatory process is one of the factors involved in many pathologies involving older people (such as ATS, AD, tumors, and type 2 diabetes). Considering the central role that the inflammatory process plays in the aging-oxidative stress process, the course focuses on: i) the inflammatory mechanisms that pay a major role during the phenomenon of human aging; ii) the characteristics of the immune system in elderly subjects usually characterized by both a de-regulation of inflammatory processes and by a reduced capability to react against pathogens and tumor. TEACHING METHODS Teaching is divided into 20 hours of classroom lectures on all the topics of the program. The teachers explain the topics through PowerPoint presentations. Students should attend at least 75% of the whole course. SYLLABUS/CONTENT 1. CELLULAR PATHOLOGY: pathogenesis of atherosclerosis 2. CANCER. Metaplasia, dysplasia, anaplasia. Classification and malignant characters. Staging systems and gradation. Chemical, physical and biologica lcarcinogenesis. Metabolism and activation of carcinogens. Initiation, promotion, progression. Invasiveness and metastasis. Outline of tumor markers. 3. Acute inflammation. Inflammatory cells. The inflammatory cytokines (IL-1, IL-6, and TNF). Chemokines. Leukocyte migration. The systemic effects of inflammation. The acute phase proteins. Chronic inflammation. The macrophages and chronic inflammation. Pathogenesis of Alzheimer disease (AD). Chronic inflammation in AD. The link between chronic inflammation and tumor progression/promotion. Oncogenes and the oncosoppressor genes. The immune system in aged individuals. RECOMMENDED READING/BIBLIOGRAPHY G.M.Pontieri :Patologia generale & fisiopatologia generale per i corsi di laurea in Professioni Sanitarie. Piccin ed. G.Barrera, R.A. Canuto, C.Gardi, G. Muzio,M.Nitti, A.Pompella: Patologia e fisiopatologia generale. Monduzzi ed. Licastro-Caruso: Compendio di patologia generale. Casa editrice Ambrosiana G.M. Pontieri: Elementi di Patologia e Fisiopatologia Generale, III edizione, Piccin ed. M. Parola:Patologia Generale, Edises ed. G.M.Pontieri :Patologia generale & fisiopatologia generale per i corsi di laurea in Professioni Sanitarie. Piccin ed. G.Barrera, R.A. Canuto, C.Gardi, G. Muzio,M.Nitti, A.Pompella: Patologia e fisiopatologia generale. Monduzzi ed. Licastro-Caruso: Compendio di patologia generale. Casa editrice Ambrosiana G.M. Pontieri: Elementi di Patologia e Fisiopatologia Generale, III edizione, Piccin ed. M. Parola:Patologia Generale, Edises ed. TEACHERS AND EXAM BOARD SUSANNA PENCO Ricevimento: Contact by e-mail : firstname.lastname@example.org or at the adress DIMES, sezione di patologia generale, via Leon Battista Alberti, 2., Genoa. GABRIELLA PIETRA Ricevimento: Students have the possibility to contact Gabriella Pietra by e-mail (email@example.com) or by phone (010 5558219) and ask for an appointment. Address 1: Laboratorio di Immunologia CBA/ Pad 90, Largo Rosanna Benzi, 10, IRCCS Ospedale Policlinico San Martino Address 2: Sezione di Patologia Generale - DIMES, Via L. Alberti, 2 Exam Board AMBRA BISIO (President) FIAMMETTA MONACELLI (President) SUSANNA PENCO (President) GABRIELLA PIETRA (President) PIERO RUGGERI (President) ANNA FASSIO (President and Coordinator of Integrated Course) LESSONS Class schedule L'orario di tutti gli insegnamenti è consultabile all'indirizzo EasyAcademy. EXAMS EXAM DESCRIPTION The final examination consists of an oral interview in the presence of the course teachers. The interview will be focused on the program content. ASSESSMENT METHODS The evaluation is carried out only through the final exam, aimed at verifiying the real acquisition by the student of the expected learning results. A minimum mark of 18/30 is required in order to pass the exam.