CODE 111612 ACADEMIC YEAR 2023/2024 CREDITS 5 cfu anno 1 CHIMICA E TECNOLOGIA FARMACEUTICHE 11674 (LM-13.) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR BIO/13 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester PREREQUISITES Propedeuticità in uscita Questo insegnamento è propedeutico per gli insegnamenti: PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY 11674 (coorte 2023/2024) MICROBIOLOGY (MODULE) 111634 MODULES Questo insegnamento è un modulo di: ANIMAL BIOLOGY AND HUMAN ANATOMY (INTEGRATED COURSE) TEACHING MATERIALS AULAWEB AIMS AND CONTENT AIMS AND LEARNING OUTCOMES The course aims at providing students with basic knowledge of the molecular mechanisms supporting the principal cell functions (from morphology and internal organization up to gene expression regulation, generation of differentiated cell lineages and genetic traits transmission). TEACHING METHODS The course includes classroom teaching on topics of Cell and Molecular Biology and Genetics. SYLLABUS/CONTENT The course is divided in six main areas: 1. Macromolecules – Topics to be developed: Basic structure and properties of nucleic acids, proteins, lipids and carbohydrates shall be presented with focus on chemical bonds and molecular structure and interactions to provide notions to understand the basic cell biology. 2. Citology – Topics to be developed: Cell morphology and structure of procariotes and eucariotes. Biological membranes (models, chemical composition and functions), cell organelles (Golgi, endoplasmic reticulum, lisosomes, peroxisomes, mitochondria, nucleus), cytoskeleton (composition and functions of the different systems). 3. Cell-cell and cell-ECM interactions - Topics to be developed: Cell junctions (different systems, meaning and functions), extracellular matrix (different forms, meaning and functions), cell communications (different systems, meaning and signaling mechanisms). 4. Gene expression - Topics to be developed: Nucleic acids structure and functions, DNA duplication, transcription, translation, gene expression regulation. 5. Cell proliferation - Topics to be developed: Cell cycle and control mechanisms, mitosis, meiosis, gametogenesis, mechanisms and meaning of cell death (apoptosis and necrosis), mechanisms of cell differentiation and cell transformation. 6. Basic genetics - Topics to be developed: Mendel’s Laws of Heredity, probability of inheritance, alleles and genes, dominant and recessive alleles, homozygous and heterozygous definitions. Sex Chromosomes and Sex-Linked Inheritance. Karyotype aneuploidy. RECOMMENDED READING/BIBLIOGRAPHY -Alberts et al.; "L'essenziale di biologia molecolare della cellula"; Zanichelli Editori. -Becker et al.; "Il mondo della cellula"; Pearsons Eds. -Solomon et al.; "Biologia"; Edises -Karp et al.; "Biologia cellulare e molecolare"; Edises -Pollard et a.; "Biologia Cellulare"; Elsevier-Masson Eds. TEACHERS AND EXAM BOARD RODOLFO QUARTO Ricevimento: By email appointment : rodolfo.quarto@unige.it Exam Board RODOLFO QUARTO (President) DANIELE SAVERINO KATIA CORTESE (President Substitute) SVEVA BOLLINI (Substitute) ROBERTA TASSO (Substitute) LESSONS Class schedule The timetable for this course is available here: Portale EasyAcademy EXAMS EXAM DESCRIPTION The exam consists of a written part consisting of 15 multiple-choice questions (along with the written part of the Human Anatomy module) and an oral part. The questions are based on the topics covered in the lectures. Successfully passing the written part (achievable with at least 9 correct answers out of 15 for each module) grants access to the oral examination, where the student's knowledge of the subject will be further assessed through a discussion with the instructor. This evaluation will also consider language proficiency, the use of appropriate terminology, and the student's ability to make connections between different concepts. ASSESSMENT METHODS The teacher will further assess the student's level of preparation by evaluating their knowledge of the subject matter and their ability to make connections between different concepts. Exam schedule Data appello Orario Luogo Degree type Note 28/03/2024 09:00 GENOVA Scritto + Orale Ore 9.00 Aula A (aula magna) - Edificio 5 (ex Dimi) 18/06/2024 09:00 GENOVA Scritto + Orale 10/07/2024 09:00 GENOVA Scritto + Orale H. 09:00 - Aula 2 Polo Alberti 24/07/2024 09:00 GENOVA Scritto + Orale Aula 2 Polo Alberti ore 9 11/09/2024 09:00 GENOVA Scritto + Orale Auletta Anatomia Umana, pianoterra, via de toni 14, ore 9.00 21/01/2025 09:00 GENOVA Scritto + Orale 04/02/2025 09:00 GENOVA Scritto + Orale