CODE 104849 ACADEMIC YEAR 2024/2025 CREDITS 6 cfu anno 2 BIOLOGIA APPLICATA E SPERIMENTALE 11158 (LM-6) - GENOVA SCIENTIFIC DISCIPLINARY SECTOR MED/04 LANGUAGE Italian TEACHING LOCATION GENOVA SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: GENERAL PATHOLOGY AND PATHOPHYSIOLOGY TEACHING MATERIALS AULAWEB AIMS AND CONTENT LEARNING OUTCOMES The course aims at providing students with the in-depht knowledge the main pathophysiological conditions as well as the immunopatholgical disorders. The deep knowledge provided in this course will be fundamental for the full understanding of laboratory medicine and then in the activities in clinical and experimental laboratories. AIMS AND LEARNING OUTCOMES The full knowledge of the pathophysiological alterations and immune system pathologies allows to understand the fundamentals of laboratory medicine, facilitating the interpretation of clinical data in the context of the organ/apparatus dysfunctions. This knowledge, complemented by the knowledge of the pathogenetic mechanisms of diseases acquired in the first module of the annual teaching, prepares future professionals in clinical/diagnostic and research laboratories. TEACHING METHODS 48 hours of lectures with multimedia presentations. Students who have valid certification of physical or learning disabilities on file with the University and who wish to discuss possible accommodations or other circumstances regarding lectures, coursework and exams, should speak both with the instructor and with Professor Sara Ferrando (sara.ferrando@unige.it), the Department’s disability liaison. SYLLABUS/CONTENT Anemias Hemostasis and thrombosis Hemorrhagic diathesis: congenital and acquired alterations. CID Vascular disorders: edema, embolism, heart attack, shock. Digestive system (gastroesophageal reflux, ulcer, Chron's disease, ulcerative colitis and pancreatitis). Pathophysiology of the liver: portal hypertension and hepatic insufficiency Pathophysiology of the heart (defects in strength, electrical changes, valve defects, acute and chronic heart failure) Pathophysiology of the lung (ventilation defects, obstructive and restrictive syndromes, gas exchange defects, significance of hypercapnia) Pathophysiology of the kidney (glomerular, tubular, interstitial, vascular and urinary tract diseases; acute and chronic insufficiency) Endocrine and genital (hypo- and hormonal hypersecretions; fertility) Immunological memory Vaccines - Principle of vaccination. Active and passive immunization. Main types of vaccines. Adjuvants. Congenital immunodeficiencies of innate and acquired immunity Secondary immune deficiencies (HIV) Autoimmunity - Mechanisms of central and peripheral tolerance. Classification of the main autoimmune diseases and their characteristics Anti-tumor immunity - Effector cells and evasion mechanisms of tumor immunosurveillance. Cancer Immunoediting. Tumor immunotherapy. Microbiome, tumors and response to anti-tumor therapies Transplants - Solid organ transplants, classification and mechanisms of rejection. Allor direct and indirect recognition. Immunosuppressive drugs. Hematopoietic stem cell transplantation RECOMMENDED READING/BIBLIOGRAPHY Information will be provided during the lessons TEACHERS AND EXAM BOARD MARIAPAOLA NITTI Ricevimento: Anytime by appointment NICOLA TRAVERSO Ricevimento: For appointments, contact the Professor via email at: Nicola.Traverso@unige.it. The teacher's office is located in the General Pathology Section of DIMES, Via Leon Battista Alberti 2, Room "Ex-direzione", 1st floor, 16132 Genoa Nicola Traverso is the Coordinator of the Integrated Course of Clinical Pathology and Immunohematology GABRIELLA PIETRA Ricevimento: Students have the possibility to contact Gabriella Pietra by e-mail (gabriella.pietra@unige.it) or by phone (010 5558219) and ask for an appointment. Exam Board MARIAPAOLA NITTI (President) ANNA LISA FURFARO NICOLA TRAVERSO GABRIELLA PIETRA (President Substitute) LESSONS LESSONS START For lessons start and timetable go to the link: https://easyacademy.unige.it/portalestudenti/ Please check the module Aulaweb page for timetable updates dependent on the sanitary and epidemic situation. Class schedule PATHOPHYSIOLOGY AND IMMUNOPATHOLOGY EXAMS EXAM DESCRIPTION Oral examination on topics covered during lessons. ASSESSMENT METHODS The student must correctly answer 3-4 questions. For final evaluation, the commission will evaluate the following requirements: the level of knowledge of the topics covered by the questions, the acquisition of specialized vocabulary and the ability to present and connect different related topics and to discuss the clinical data in the context of the organ/apparatus dysfunctions. During the exam, the rules regarding the assessment method of DSA certified students or students with other educational needs indicated by the university will be respected. (e.g.: additional time, use of concept maps to be viewed for approval by the teachers at least one week before the exam date). Exam schedule Data appello Orario Luogo Degree type Note 17/01/2025 09:00 GENOVA Orale 31/01/2025 09:00 GENOVA Orale 21/02/2025 09:00 GENOVA Orale 27/06/2025 09:00 GENOVA Orale 18/07/2025 09:00 GENOVA Orale 19/09/2025 09:00 GENOVA Orale FURTHER INFORMATION Students who have valid certification of physical or learning disabilities on file with the University and who wish to discuss possible accommodations or other circumstances regarding lectures, coursework and exams, should speak both with the instructor and with Professor Sara Ferrando (sara.ferrando@unige.it), the Department’s disability liaison.