LEARNING OUTCOMES

At the end of the course the student is able to discuss, on the basis of the characteristics of the chemical structure of the molecule, its interactions at molecular level with the biological target and therefore the student is able to better understand the therapeutic use of that specific drug. Furthermore, the student is able to identify the main points for metabolic attack and therefore, toxicity,  generally speaking or for particular classes of patients. The student knows how to identify any negative or positive association between drugs. He/she can identify any "off-label" use of the drug.

AIMS AND LEARNING OUTCOMES

Objective of the course is to make the student able to analyze the type of drug, its ability to pass the blood-brain barrier, its metabolic reactions, the possible formation of active metabolites, its toxicity on the basis of the chemical structure of the molecule. The ability to predict and discuss interactions at the molecular level with the biological target is also acquired

PREREQUISITES

A good knowledge of basic chemistry, in particular organic chemistry, is required to take the course successfully and derive the maximum benefit from it in terms of learning. The notions learned in the courses of Biochemistry, General Pharmacology and obviously General Pharmaceutical Chemistry and Pharmaceutical Chemistry I are also very useful.

TEACHING METHODS

The course consists of about 48 lessons of two hours each, held in person. During the lessons slides, available for students, are used.

SYLLABUS/CONTENT

Knowledge of chemical formula, mechanism of action, molecular interactions with the biological target, structure-activity correlations, dosage, commercial name, main metabolites, side effects, interactions with other drugs for the following class of drugs (the complete list is  reported in Manifesto): anxiolytic, sedative and hypnotic drugs - antiepileptic drugs - antidepressant drugs - neuroleptic drugs - opiate analgesics - cannabinoids - CNS stimulants - drugs active on the peripheral nervous system, drugs for the treatment of Parkinson's disease, Alzheimer's disease, non-steroidal anti-inflammatory drugs, antirheumatic drugs, antigout drugs, drugs for heart and circulation, diuretics, antiarrhythmic drugs, antihypertensive drugs, drugs for erectile dysfunction, antitussive drugs.

RECOMMENDED READING/BIBLIOGRAPHY

G. Patrick, Chimica Farmaceutica, Ed. curata da G. Costantino, Edises

Gasco et al., Chimica Farmaceutica, Ed. Ambrosiana