CODE 72707 ACADEMIC YEAR 2022/2023 CREDITS 1 cfu anno 1 9276 (L/SNT1) - IMPERIA SCIENTIFIC DISCIPLINARY SECTOR BIO/13 LANGUAGE Italian TEACHING LOCATION GENOVA CHIAVARI SAVONA LA SPEZIA IMPERIA GE GALLIERA GE ASL 3 GE SAN MARTINO SEMESTER 1° Semester MODULES Questo insegnamento è un modulo di: PHYSICS, BIOLOGY, GENETICS AND STATISTICS TEACHING MATERIALS AULAWEB OVERVIEW The course will introduce students to the basic concepts of molecular and cellular biology, starting from the morphological and structural description of the cell. The course will describe the biological processes that regulate the handling of genetic information, of protein synthesis and of cell reproduction and organization. The course will also present an overview of embryonic development to evidence the specific hierarchical organization of molecular effectors to drive the development of individual organisms AIMS AND CONTENT AIMS AND LEARNING OUTCOMES AIMS Lessons aim to introduce students to the basic and most relevant aspects of cell biology, so that, at the end of the course, students will be able to interpret the cell as a functional unit of structures of superior hierarchical order (tissue, organs, and individuals) and as suitable target of therapeutic and pharmacological treatments. LEARNING OUTCOMES (DETAILED) Students are required to retain knowledge of molecular and functional cellular mechanisms that allow the existence of living organisms, as well as to comprehend their significance in relation to other cells and the surrounding microenvironment. Students must also know, comprehend and be able to compare the molecular mechanisms that allow to control and to direct the genetic information that drives the developmental plan of living organisms; they will also be required to critically evaluate the possible effects of alterations of main cellular functions and their biological consequences. Students will also be expected to retain and use the proper scientific terminology. TEACHING METHODS Classes will be managed as frontal lectures with Power Point presentations; during classes, students will be engaged in active discussion, via examples and specific exercises. If necessary, lessons may be provided on-line, through specific platforms and pre-arrangements made between the teacher, the students and the different Schools in the region. Students can take advantage of online material (lectures power point notes) available on the AulaWeb website; the teacher can be reached via email to arrange specific one-to-one meeting for further assistance/explanation as needed SYLLABUS/CONTENT Introduction to the “cell theory”; prokaryotic and eukaryotic cells; the endo-symbiotic theory; structure and functions of the cell membrane; membrane transportation: simple and facilitated diffusion, passive and active transportation (ion channels and transporters); endo- and exocytosis. Chemical composition and structure of DNA; molecular mechanisms of DNA replication in prokaryotic and eukaryotic cells; transcription and characteristics of m-, r-, and of t-RNA. Translation and the genetic code; role of mRNA, tRNA and of ribosomes. Proteins: their structures and roles inside the cell; enzymes and structural proteins. Cell cycle and its control in eukaryotic cells (growth factors, oncogenes and onco-suppressor proteins). Mechanisms of cell communication; membrane and intracellular receptors; overview of signal transductions. Apoptosis. Overview of the basic mechanisms that control cell differentiation and embryonic development. RECOMMENDED READING/BIBLIOGRAPHY Power point notes of class lectures are available for students to be downloaded from AulaWeb (https://sanitarie.aulaweb.unige.it/course/search.php?search=biologia). Files are strictly for personal use only; files must not be shared on social media, posted on any internet website or put on any sharing platform; files must not be printed out for sale or photocopied. Other basic biology and genetics textbooks can be also used, providing they are intended for University Master Degree courses, among which the ones indicated below: D. Sadava et al.; Biologia: 1La cellula. Zanichelli Ed. D. Sadava et al.; Biologia: 2L’ereditarietà ed il genoma. Zanichelli Ed. E.P. Solomon et al., Elementi di Biologia. EdiSes Ed. Alberts et al. “L’essenziale di biologia molecolare della cellula”, Zanichelli Ed. TEACHERS AND EXAM BOARD SVEVA BOLLINI Ricevimento: Prof. Sveva Bollini office hours for students are normally set by previous appointment requested by email. The office address is: Biology Section, Dept. Experimental Medicine; entrance: Via Pastore 3 or C.so Europa 30, second floor or Torre C3, c/o CBA, Cellular Oncology Lab, L. go R. Benzi 10, 16132 Genova. The lecturer's e-mail address and phone number are the following: firstname.lastname@example.org; 0105558394. If necessary appointments may also take place on-line, depending on previous agreements between students and lecturer. WILLIAM BRUNO Ricevimento: Prof. W. Bruno can be reached for an appointment by email (William.email@example.com). The office address is: DIMI, II° floor, V.le Benedetto XV, 6. Online appointments (preferentially by Microsoft Teams platform) are offered. ROBERTA TASSO Ricevimento: Prof. Roberta Tasso: The office address is: Biology Section, Dept. Experimental Medicine; entrance: Via Pastore 3 or C.so Europa 30, second floor. The teacher's e-mail address is the following: firstname.lastname@example.org. Alternatively, the teacher can be reached at the following phone number: 0105558394. If necessary, appointments may also take place on-line, depending on previous agreements between the students and the teacher. PAOLO GIANNONI Ricevimento: Prof. Paolo Giannoni: Office hours for students are normally set on Thursdays from 09:00 to 11:00. The office address is: Biology Section, Dept. Experimental Medicine; entrance: Via Pastore 3 or C.so Europa 30, second floor. E-mail appointments are strongly encouraged. The teacher's e-mail address is the following: email@example.com. Alternatively the teacher can be reached at the following phone number: 01035338201. If necessary appointments may also take place on-line, depending on previous agreements between the students and the teacher. Exam Board LILIANA BELGIOIA EMILIA BELLONE RENATA BOCCIARDI SVEVA BOLLINI WILLIAM BRUNO EMILIO DI MARIA ROBERTO EGGENHOFFNER PAOLO GIANNONI MASSIMO MARESCA ALDAMARIA PULITI PAOLO SCUDIERI ROBERTA TASSO GIANNI VIARDO VERCELLI FRANCESCA LANTIERI (President and Coordinator of Integrated Course) RENATA BOCCIARDI SVEVA BOLLINI ROBERTO EGGENHOFFNER LESSONS LESSONS START According to the formal communication provided by the competent office of each Faculty/School Class schedule L'orario di tutti gli insegnamenti è consultabile all'indirizzo EasyAcademy. EXAMS EXAM DESCRIPTION The exam is a written text –either to be taken on-line or in presence- during which students are requested to answer 10 questions relating each of the integrated course single teaching. Questions will span through all main items/topics presented during the course. Different types of questions will be used, such as multiple choices, correlation questions and graphical questions (mainly referring to pictograms/schemes already presented during classes). The test will be timed, allowing 10 minutes for each set of 10 questions (this applies both for on-line and in presence test sessions). ASSESSMENT METHODS The exam aims to verify the students’ comprehension of cell morphology and general organization, as well as their knowledge of the differences/similarities among prokaryotic and eukaryotic cells and of their vital functions. The exam aims to assess the student’s knowledge of the molecular biology central dogma and of the molecular mechanisms that drive cell development. The students’ ability to memorize specific terms/statements and to correlate them with specific cellular functions/activities shall be evaluated, primarily, by correlation questions. Different additional types of questions, among which multiple choice questions, will also be used to evaluate the students’ competence relating molecular and functional cellular activities. The appropriateness of the students’ understanding about cause/effect correlations, control mechanisms, as well as organelle structures and/or morphological aspects may also be examined by their answers to graphical questions. Exam schedule Data Ora Luogo Degree type Note 17/01/2023 09:00 GENOVA Frazione B - con accettazione online 13/02/2023 14:00 GENOVA Frazione B - con accettazione online 14/06/2023 09:00 GENOVA Frazione B - con accettazione online 10/07/2023 09:00 GENOVA Frazione B - con accettazione online 07/09/2023 09:00 GENOVA Frazione B - con accettazione online FURTHER INFORMATION Registration for the exams is strictly limited to the on-line registration system. No students will be allowed to take the exam if not enrolled or if enrolled by any other means. If students experience troubles/inconveniences while enrolling, they are strongly encouraged to contact the on-line student service IN ADVANCE to the enrolment deadline. Topics covered during lessons are summarized by the power-point presentations available on the AulaWeb page. Additional material can be presented at the end of the front lesson and made available through AulaWeb (https://www.aulaweb.unige.it).