The first part of the course aims to provide the basis of general and organic chemistry to address Biochemistry, the second part of the course. The aim of this second part is both the acquisition of knowledge about the structure and function of proteins and enzymes proteins as the main pathways of carbohydrate, fat, and protein catabolism.
The course is done in blended. The lectures in presence are supported / supplemented by lectures recorded that the students can access online through the platform AulaWeb
PROPEDEUTICAL BIOCHEMISTRY solutions. Properties and units of measure: molarity, normality,% w / w% w / v. osmotic pressure. The chemical reactions. chemical balance. chemical kinetics. Reaction speed. Catalysis and enzymatic catalysis, Km. Thermodynamics. Concepts of enthalpy and entropy. Spontaneity of reactions, free energy. Ionization of water. pH. Acidity and alkalinity. Strong and weak acids and bases, hydrolysis, buffers. The chemistry of carbon, the carbon valence. The functional groups. Alcohols and thiols. Redox reactions. Oxidation of alcohols and thiols. Aldehydes and ketones. Hemiacetals. Amines. Carboxylic acid. Amides, esters and anhydrides. Fatty acids. Triglycerides. Phospholipids. Biomolecules and their functional groups. Carbohydrates: Monosaccharides: glucose, fructose, ribose and deoxyribose, disaccharides: sucrose, and polysaccharides, cellulose, glycogen. Amino acids. Peptides and proteins. The peptide bond. protein structure.
Biochemistry Myoglobin. Hemoglobin. Enzymes: structure and function. Catabolism and anabolism: general concepts of the intermediate metabolism. Glycolysis, gluconeogenesis and glucose: regulation. Lactate cycle. Krebs cycle. Strategies for ATP synthesis. Synthesis and degradation of glycogen. Oxidation of fatty acids. Chetonic bodies. Amino acids catabolism: urea cycle.
Catani, Savini, Guerrieri, Avigliano “Appunti di Biochimica per le lauree triennali” Editore: Piccin Stefani, Taddei “Chimica biochimica e biologia applicata” Editore: Zanichelli
Ricevimento: On appointment Prof. Umberto Benatti, Viale Benedetto XV, 1 - 16132 Genova Tel: 010-3538151 e-mail: benatti@unige.it
second semester AY 2018/2019
Oral exam. The exam lasts about 20 minutes per student and is carried out on the topics covered in class and taken up, in part, in the videotaped lessons available online on AulaWeb.
For the units with video lessons, self-assessment tests, which are designed to stimulate students in learning, are provided. Self-assessment tests are useful also to verify the correct understanding, facilitating the preparation of the final exam, done in the presence.
