This course provides a basic outline of the principles of classical genetics Methods to determine the relative positions of genes in the genome are explained, and various patterns of inheritance are described. The main areas that are covered are: transmission genetics, gene and genome structure, stability and variability mechanisms. The course also provides students with the skills to solve simple genetic problems .This is carried out by using an interactive approach.a
The course provides basic knowledge of
-general mechanisms of inheritance, with particular attention to human heredity
-fundamentals of molecular genetics mechanisms that underlie monogenic inheritance models .
-basic features of the process and the molecular basis of mutations
-potential medical applications using simulation exercises
The course consists of frontal interactive lectures with assistance in solving simple genetic problems
Mitosis versus Meiosis
Basic principles of inheritance: applications of Mendel's principles to eukaryotes followed by an introduction to humans (notions of features of autosomal dominant and recessive inheritance)
Sex-chromosomes and the chromosomal theory of inheritance. Sex-linked traits
Extensions of Mendel's classic genetics: allelic variations, gene-gene interactions, gene-environment interactions
Linked genes: recombination and gene mapping in eukaryotes.
Basic features of mutations: molecular basis of mutation and different phenotypic effects. Chemical and physical mutagens.
All the topics and lecture notes can be found in the ”aula web” slides: https://www.aulaweb.unige.it
Ricevimento: By appointment. Please contact the Lecturer by e-mail (william.bruno@unige.it).
Ricevimento: Soon after lecture hours or by appointment, please contact the Lecturer by email: sveva.bollini@unige.it
Ricevimento: Office hours for students are normally set on Thursdays from 09:00 to 11:00. The office address is: Biology Section, Dept. Experimental Medicine, entrance: Via Pastore 3 or C.so Europa 30, second floor. E-mail appointments are strongly encouraged. The teacher's e mail address is the following: paolo.giannoni@unige.it. Alternatively the teacher can be reached at the following phone number: 01035338201.
Written multiple choice test. The assessment of the integrated course is made up of a single written exam for the 4 sub-sections(10 multiple choice questions per each module: Biology, Genertal Genetics, Medical Genetics and Microbiology). In order to pass the class athe student has to reach a mark of at least 24/40 (18/30).
The total amount of time allowed for the exam is 60 minutes. Students enrolled in other universities or other degree courses who are only required to sit for some of the sub-sections must achieve an average mark of at least 6, 12 or 18, depending on the number of modules
Students are assessed by a final exam alone which aims to ensure that they have actually reached the required level of knowledge. In order to pass the class, students must reach a mark of at least 18/30.
All the topics covered in class can be found in the ”aula web” slides. Any other, more in-depth material is mentioned at the end of the lesson and can be found in the “aula web” slides. https://www.aulaweb.unige.it
Students must make an appointment to talk to professors.(e-mail phone
